A common and challenging data and modeling aspect in crash analysis is unobserved heterogeneity, which is often handled using random parameters and special distributions such as Lindley. Random parameters can be estimated with respect to each observation for the entire dataset, and grouped across segments of the dataset, with variable means, or variable variances. The selection of the best approach to handle unobserved heterogeneity depends on the data characteristics and requires the corresponding hypothesis testing. In addition to dealing with unobserved heterogeneity, crash frequency modeling often requires explicit consideration of functional forms, transformations, and identification of likely contributing factors. During model estimation, it is important to consider multiple objectives such as in- and out-of-sample goodness-of-fit to generate reliable and transferable insights. Taking all of these aspects and objectives into account simultaneously represents a very large number of modeling decisions and hypothesis testing. Limited testing and model development may lead to bias and missing relevant specifications with important insights. To address these challenges, this paper proposes a comprehensive optimization framework, underpinned by a mathematical programming formulation, for systematic hypothesis testing considering simultaneously multiple objectives, unobserved heterogeneity, grouped random parameters, functional forms, transformations, heterogeneity in means, and the identification of likely contributing factors. The proposed framework employs a variety of metaheuristic solution algorithms to address the complexity and non-convexity of the estimation and optimization problem. Several metaheuristics were tested including Simulated Annealing, Differential Evolution and Harmony Search. Harmony Search provided convergence with low sensitivity to the choice of hyperparameters. The effectiveness of the framework was evaluated using three real-world data sets, generating sound and consistent results compared to the corresponding published models. These results demonstrate the ability of the proposed framework to efficiently estimate sound and parsimonious crash data count models while reducing costs associated with time and required knowledge, bias, and sub-optimal solutions due to limited testing. To support experimental testing for analysts and modelers, the Python package "MetaCountRegressor," which includes algorithms and software, is available on PyPi.
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http://dx.doi.org/10.1016/j.aap.2024.107844 | DOI Listing |
J Affect Disord
December 2024
UCL Social Research Institute, University College London, London, UK. Electronic address:
Background: Research suggests that individuals' local social networks, norms of reciprocity and sense of belonging (their local social capital, henceforth LSC), can cushion the impact of adverse events on their mental health. However, to date, little research has explored the pathways through which LSC operates to buffer stressors, especially during major crises, e.g.
View Article and Find Full Text PDFNPJ Syst Biol Appl
January 2025
School of Mathematical Science, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.
CITE-seq provides a powerful method for simultaneously measuring RNA and protein expression at the single-cell level. The integrated analysis of RNA and protein expression in identical cells is crucial for revealing cellular heterogeneity. However, the high experimental costs associated with CITE-seq limit its widespread application.
View Article and Find Full Text PDFBMC Med Res Methodol
December 2024
Janssen Research & Development LLC, Global Epidemiology Organization, Raritan, NJ, USA.
Background: Autoimmune disorders have primary manifestations such as joint pain and bowel inflammation but can also have secondary manifestations such as non-infectious uveitis (NIU). A regulatory health authority raised concerns after receiving spontaneous reports for NIU following exposure to Remicade, a biologic therapy with multiple indications for which alternative therapies are available. In assessment of this clinical question, we applied validity diagnostics to support observational data causal inferences.
View Article and Find Full Text PDFBiometrics
October 2024
Evidence Generation and Advanced Analytics Biogen Digital Health, Biogen, Cambridge, MA 02142, United States.
In many clinical contexts, the event of interest could occur multiple times for the same patient. Considerable advancement has been made on developing recurrent event models based on or that use biomarker information. However, less attention has been given to evaluating the prognostic accuracy of a biomarker or a composite score obtained from a fitted recurrent event-rate model.
View Article and Find Full Text PDFInquiry
December 2024
Department of Economics, University of Kashmir, Srinagar, India.
This study investigates the relationship between out-of-pocket (OOP) healthcare spending, economic growth, population growth, and government health expenditure as a proportion of general government expenditure using National Health Accounts (NHA) estimates. Out-of-Pocket (OOP) healthcare spending imposes a substantial financial burden on households, especially in developing economies such as India. Understanding the factors that influence OOP payments is crucial for policymakers seeking to enhance healthcare systems and achieve Universal Health Coverage (UHC).
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