This study investigates the effects of Pt and Ru complexes containing a Schiff base with a diimine structure on Alzheimer's disease. The Schiff base (N1E,N2E)-N1,N2-bis(isoquinolin-4-ylmethylene)benzene-1,2-diamine (I) and the novel Pt(II) and Ru(II) complexes (Ia and Ib) were synthesized and characterized using FTIR, NMR (H, C), mass spectrometry, and elemental analyses. Their ability to inhibit amyloid beta (Aβ) aggregation was determined in vitro using the SH-SY5Y cell line. Fluorescence spectroscopy investigated the early aggregation kinetics and dose-dependent characteristics of Aβ with the complexes. Transmission electron microscopy confirmed the results. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and H NMR spectroscopy examined the interaction with Aβ. Electrochemical analysis using square wave voltammetry monitored the interaction with Aβ. The synthesized complexes were active in inhibiting amyloid aggregation at a low molar ratio.
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