Severity: Warning
Message: fopen(/var/lib/php/sessions/ci_sessioni9o8gor8oc113muinm687d4og2jq81i1): Failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 177
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
Line Number: 137
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 143
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: Attempt to read property "Count" on bool
Filename: helpers/my_audit_helper.php
Line Number: 3100
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler
File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Objective: Evidence from cross-sectional studies mainly among postmenopausal women suggests that biological aging is associated with reproductive senescence. We evaluated the prospective association of cellular markers of biological aging measured during the premenopausal period, and changes in these markers, with age at menopause.
Methods: We studied 583 premenopausal women (39% Black) from the Coronary Artery Risk Development in Young Adults Study who had data on biological aging markers in 2000-2001 and reached menopause by 2020-2021. Linear regression models were used to evaluate the association of telomere length, mitochondrial DNA copy number, intrinsic or extrinsic epigenetic age acceleration, and PhenoAge or GrimAge acceleration with age at menopause.
Results: The mean age at baseline was 41.2 ± 3.3 years, with the mean age at menopause being 49.1 (median, 50) years. About one in five women had surgical menopause. In chronological age-adjusted models, only baseline GrimAge acceleration was associated with age at menopause; women whose epigenetic age was older than their chronological age reached menopause at 0.12 years (~6 weeks) earlier compared with women with equal epigenetic and chronological age (β = -0.123; 95% CI, -0.224 to -0.022; P = 0.018). However, this association was not statistically significant after adjustment for sociodemographic, behavior/lifestyle, and metabolic factors. Similar results were observed when changes in these biological aging markers were evaluated. The same associations were observed in analyses limited to women who reached natural menopause.
Conclusions: Sociodemographic, behavior/lifestyle, and metabolic factors remain comparable, if not more robust predictors of the age at menopause compared with cellular measures of biological age.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/GME.0000000000002457 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!