The development of sarcoma within a glioblastoma is a well recognised complication: in the majority of cases it is a fibro-sarcoma originating in the tissues of the proliferating hyperplastic blood vessels. In the case described here the tumour is a rhabdomyosarcoma, apparently derived from abnormal prolific vascular mesenchyme. Only one comparable example has been recorded previously.
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Gliosarcoma with prominent smooth muscle component (gliomyosarcoma): a report of 10 cases.
Indian J Pathol Microbiol
June 2011
Department of Pathology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi 110 060, India.
Background And Aim: Gliosarcoma (GS) is an uncommon malignant tumor of the brain, consisting of malignant glial, usually a glioblastoma (GB), as well as sarcomatous component; the latter is usually in the form of fibrosarcoma. We report a series of 10 GSs with prominent smooth muscle component, which is a rare occurrence.
Settings And Design: Out of a series of 225 cases of GB admitted in our hospital, 10 were diagnosed as GS with prominent smooth muscle component, gliomyosarcoma (GMS).
Penetration failure and misdiagnosis of stereotactic biopsy caused by the uncommonly firm tissue of a gliomyosarcoma.
Minim Invasive Neurosurg
September 2002
Department of Neurosurgery, Donauspital SMZ-Ost, Vienna, Austria.
Objective And Importance: We report the very rare case of a gliomyosarcoma that caused penetration failure in stereotactic biopsy and therefore led to misdiagnosis. This complication should be considered as a potential reason for diagnostic failure with uncommonly firm tumors in frame-based stereotactic biopsy.
Clinical Presentation: An 83-year-old women presented with a 4-week history of right hemiparesis.
[Malignant glial tumor with skeletal muscle differentiation. Description of a case].
Pathologica
June 2000
Dipartimento di Oncologia, M. Malpighi, Università di Bologna, Ospedale Bellaria.
A case of CNS gliomyosarcoma, in a 71-year-old female with skeletal muscle differentiation is presented. The tumor was composed by two cell types: one showed features typical of glial cells, the other was constituted by elements having immunohistochemical positivity with desmin, sarcomeric actin, myoglobin and myogenin antisera. It is postulated an origin from a cell capable of dual differentiation.
View Article and Find Full Text PDFA clinico-pathological study of 29 cases of gliosarcoma with special reference to two unique variants.
Indian J Med Res
September 1997
Department of Pathology, All India Institute of Medical Sciences, New Delhi.
In the present series, the clinical and pathological features of 29 patients of gliosarcoma diagnosed over a 12 yr period (1984-1995) are reviewed. Gliosarcomas constituted 0.48 per cent of all intracranial tumours and 4.
View Article and Find Full Text PDFGliomyosarcoma: an immunohistochemical analysis.
J Neurol Neurosurg Psychiatry
August 1992
Department of Neurosurgery, Atkinson Morley's Hospital, Wimbledon, London, UK.
Tumours of mixed glial and sarcomatous elements occurring in intracranial neoplasms are well recognised and have been termed gliosarcomas. These tumours account for up to 8% of all glioblastomas. The sarcomatous elements are thought to derive from the neoplastic transformation of mesenchymal cells in or adjacent to the tumour.
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