AI Article Synopsis
- The study investigates how fatty acids (FAs) influence inflammatory responses in celiac disease (CD) patients of different ages, revealing varying levels of certain FAs between children and adults.
- Results showed that while myristoleic acid decreased in children with CD, it increased in adults, along with elevated pro-inflammatory cytokines like IL-6 and TNF-α in both groups.
- The research suggests that targeting fatty acids might improve treatment strategies for CD by considering factors such as age, disease duration, and dietary differences.
Article Abstract
Background: Fatty acids (FAs) play pivotal roles in modulating inflammatory pathways in celiac disease (CD). The present study explored the relationship between serum FAs levels and the expression of both pro- and anti-inflammatory cytokines in adult and pediatric patients with CD.
Methods: Serum FA levels in 20 treated CD patients (11 children, 9 adults) and 20 healthy controls (10 children, 10 adults) were analyzed using gas chromatography. Cytokine gene expression (IL-6, TNF-α, IL-10, IL-12, TGFβ, NF-κB) was assessed through quantitative real-time PCR.
Results: Myristoleic acid levels decreased in children with CD ( = 0.03) but increased in adults ( = 0.04). Elevated IL-6 mRNA expression was found in both pediatric ( = 0.01) and adult ( = 0.04) groups. TNF-α expression was significantly higher in adults ( = 0.01). In children, IL-10 mRNA levels positively correlated with palmitic acid ( = 0.01, = 0.73), and TGF-β correlated with myristoleic acid ( = 0.03, = 0.63). In adults, IL-10 positively correlated with dihomo-gamma-linolenic acid ( = 0.04, = 0.68) and negatively with linoleic acid ( = 0.02, = -0.72). These age-related differences may reflect variations in disease duration, metabolic and developmental factors, dietary intake, and gut microbiota composition.
Conclusion: These findings suggest that FAs could be therapeutic targets for improving CD management across different age groups.
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| http://dx.doi.org/10.1080/21688370.2024.2435552 | DOI Listing |
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