Influence of vitamin D supplementation and the vaginal microenvironment on human papillomavirus infection.

Afr J Reprod Health

Department of Gynecology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.

Published: October 2024

AI Article Synopsis

  • The study investigated how the vaginal microenvironment affects HPV infection and the role of vitamin D in this context, using data from 512 participants categorized into HPV positive and negative groups.
  • It was found that the high-risk HPV (HR-HPV) group had higher abnormal rates of certain microbial and biochemical markers compared to the HPV negative group, indicating a link between these factors and HPV infection.
  • Vitamin D supplementation showed promise in reducing the persistence of HR-HPV after treatment, while also improving overall nutritional and metabolic health by lowering inflammation and other risk factors.

Article Abstract

This was a retrospective study, mainly explored the mediating role of vaginal microenvironment and the influence of vitamin D addition on human papillomavirus (HPV) infection. Five hundred and twelve participants were chosen in this study, followed by dividing into HPV positive (212 cases) and negative groups (300 cases) based on HPV 23 typing results. The high-risk human papillomavirus (HR-HPV) positive group showed higher abnormal rates of lactobacillus, catalase, cleanliness, sialidosidase, and proline aminopeptidase than the HPV negative group. No significant differences were found in pH value, leukocyte esterase, and Acetylglucosaminidase abnormality between 2 groups. The HR-HPV positive group presented a higher percentage of patients with cleanliness III and IV. Relative to low-grade squamous intraepithelial lesion (LSIL) group, HSIL group presented a higher HPV positive infection rate. Mould infection, Gardnerella infection, and catalase were identified as independent risk elements for HR-HPV infection. Vitamin D supplementation was found to potentially reduce HR-HPV infection persistence post-Loop Electrosurgical Excision Procedure (LEEP), improve nutritional health, reduce insulin, insulin resistance (HOMA-IR) and triglyceride levels, as well as reduce high-sensitivity C-reactive protein (hs-CRP) along with malondialdehyde (MDA) levels. Our results indicate that HR-HPV infection is intimately associated with the condition of the vaginal microenvironment, and vitamin D addition potentially reduces the persistence of HR-HPV infection post-LEEP, improves nutritional and metabolic health, reduces inflammation, and be well-tolerated.

Download full-text PDF

Source
http://dx.doi.org/10.29063/ajrh2024/v28i10.9DOI Listing

Publication Analysis

Top Keywords

hr-hpv infection
16
vaginal microenvironment
12
human papillomavirus
12
infection
9
influence vitamin
8
vitamin supplementation
8
vitamin addition
8
hpv positive
8
hr-hpv positive
8
positive group
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!