[Managing and planning pregnancy in patients with epilepsy].

Rev Prat

Unité d'épilepsie et de réhabilitation neurologique, hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France. Centre de recherche de l'Institut du cerveau et de la moëlle épinière (ICM), UPMC-UMR 7225 CNRS-UMRS 975 Inserm, Paris, France. Université Paris Sorbonne, France.

Published: November 2024

AI Article Synopsis

  • Managing pregnancy in women with epilepsy requires a team-based approach and careful planning to ensure the health of both mother and child.
  • Research from pregnancy registries has shed light on the harmful effects of certain antiepileptic medications, notably sodium valproate and topiramate, which can impact fetal development.
  • It's crucial to monitor the postpartum phase as well, including considerations for breastfeeding, watching for postpartum depression, and adjusting medication doses as needed.

Article Abstract

MANAGING AND PLANNING PREGNANCY IN PATIENTS WITH EPILEPSY. Managing the pregnancy of a patient with epilepsy involves multidisciplinary management and pregnancy planning. Thanks to pregnancy registries, the impact of certain antiepileptic drugs in terms of teratogenicity and neurodevelopment is better known. Two anti-epileptic drugs are particularly deleterious in this respect: sodium valproate and topiramate. Data are awaited on the most recent molecules. The postpartum period should also be closely monitored: management of breastfeeding, screening for postpartum depression, rebalancing of antiepileptic drug dosages.

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