AI Article Synopsis
- * The authors suggest new metrics to measure how well vaccines stimulate CD8 T cells and identify key viral parts that trigger immune response, considering genetic differences among people and viral changes.
- * The proposed methods were tested successfully using proteins from the Ebola virus and SARS-CoV-2 vaccines, showing the effectiveness of their approach.
Article Abstract
Vaccines have historically played a pivotal role in controlling epidemics. Effective vaccines for viruses causing significant human disease, , Ebola, Lassa fever, or Crimean Congo hemorrhagic fever virus, would be invaluable to public health strategies and counter-measure development missions. Here, we propose coverage metrics to quantify vaccine-induced CD8 T cell-mediated immune protection, as well as metrics to characterize immuno-dominant epitopes, in light of human genetic heterogeneity and viral evolution. Proof-of-principle of our approach and methods are demonstrated for Ebola virus, SARS-CoV-2, and (vaccine) proteins.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608996 | PMC |
| http://dx.doi.org/10.3389/fimmu.2024.1420284 | DOI Listing |
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