AI Article Synopsis
- - The rise of drug resistance in cancer treatment poses significant challenges, often resulting in cancer recurrence due to various mechanisms, including epigenetic alterations.
- - Histone deacetylases (HDACs) are crucial in regulating chromatin through epigenetic changes, impacting gene expression and playing a role in developing drug resistance.
- - This review highlights how HDACs contribute to the mechanisms of drug resistance, which can affect the efficacy of chemotherapy and other cancer therapies.
Article Abstract
The emergence of drug resistance leading to cancer recurrence is one of the challenges in the treatment of cancer patients. Several mechanisms can lead to drug resistance, including epigenetic changes. Histone deacetylases (HDACs) play a key role in chromatin regulation through epigenetic mechanisms and are also involved in drug resistance. The control of histone acetylation and the accessibility of regulatory DNA sequences such as promoters, enhancers, and super-enhancers are known mechanisms by which HDACs influence gene expression. Other targets of HDACs that are not histones can also contribute to resistance. This review describes the contribution of HDACs to the mechanisms that, in some cases, may determine resistance to chemotherapy or other cancer treatments.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609180 | PMC |
| http://dx.doi.org/10.20517/cdr.2024.103 | DOI Listing |
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