AI Article Synopsis
- PDGFRβ is a receptor tyrosine kinase that plays a crucial role in cell functions, and its dysregulation can lead to cardiovascular and fibrosis-related diseases.
- * Its kinase activity is tightly regulated, involving mechanisms like autoinhibition and transphosphorylation, but additional factors are needed for full regulation.
- * The study suggests that activation through dimerization and allosteric regulation is important, a mechanism also seen in other type III RTKs, such as CSF1R, which is linked to neurological issues when disrupted.
Article Abstract
Platelet-derived growth factor receptor beta (PDGFRβ), a type III receptor tyrosine kinase (RTK) with a featured kinase insert, regulates important cellular functions. Dysregulation of PDGFRβ is associated with cardiovascular and fibrosis diseases. Thus, its kinase activity needs to be precisely regulated under physiological conditions. Early studies demonstrated that its kinase is autoinhibited by its juxtamembrane segment and activated by transphosphorylation. However, additional mechanisms are required for the comprehensive regulation of the receptor kinase. Herein, we provide evidence that dimerization of activated kinases, autoinhibition by the kinase insert, and dimerization of inactive kinase, all contribute to the regulation of the receptor kinase. Moreover, we find such multiple allosteric regulation is also conserved in other type III RTKs, including colony stimulating factor 1 receptor (CSF1R). Impaired allosteric regulation of CSF1R is associated with malfunctions of microglia and demyelination of neurons in hereditary diffuse leukoencephalopathy with spheroids (HDLS).
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| http://dx.doi.org/10.3724/abbs.2024205 | DOI Listing |
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