School Absence as Functional Impairment of Juveniles with Personality Disorders Based on ICD-11 This longitudinal study focused on the question whether specialized treatment with applied transference focused psychotherapy in a day hospital program can improve school dysfunction in adolescents with borderline and other personality disorders (PD). Moreover, we investigated influential factors for the improvement of school attendance. Among the 175 juvenile patients, before treatment 60 % showed school absence. Our results indicate that the treatment could improve school attendance significantly. At the same time, we could show that some psychological variables can be considered essential predictors for the development of attending school regularly. More conduct problems and dissocial behavior diminished the likelihood to attend school increasingly regular; the higher borderline and avoidance PD criteria were fulfilled, the higher were the odds to improve school attendance. With respect to the changes regarding functional impairment of PD in the upcoming ICD-11 our results could generate knowledge that school dysfunction in adolescents with PD can be improved significantly with applied transference focused psychotherapy in a day hospital program, especially in juveniles with borderline and avoidant PD. The alteration in ICD-11 with its focus on functional impairment enables to assess and treat this problem earlier in adolescence. A specific focus for future research based on ICD-11 should address the issue how juveniles with pd, school dysfunction and conduct problems can benefit more from treatment.
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http://dx.doi.org/10.13109/prkk.2024.73.8.700 | DOI Listing |
Int J Soc Psychiatry
January 2025
Faculty of Education, University of Miyazaki, Miyazaki, Japan.
Background: Currently, paradoxical findings exist regarding the level of functioning in individuals with Hikikomori (prolonged social withdrawal).
Aims: This systematic review aimed to clarify the functioning, disability, and health of individuals with Hikikomori and their families in comparison to those without Hikikomori.
Method: Relevant studies were searched from April 22 to 25, 2022, using MEDLINE, PsycINFO, Scopus, and two Japanese databases.
Adv Sci (Weinh)
January 2025
Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, P. R. China.
MicroRNAs (miRNAs) are associated with amyloid-β (Aβ) dysmetabolism, a pivotal factor in the pathogenesis of Alzheimer's disease (AD). This study unveiled a novel miRNA, microRNA-32533 (miR-32533), featuring a distinctive base sequence identified through RNA sequencing of the APPswe/PSEN1dE9 (APP/PS1) mouse brain. Its role and underlying mechanisms were subsequently explored.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
Max Bergmann Center of Biomaterials Dresden, Leibniz-Institut für Polymerforschung Dresden e. V., Hohe Str. 6, 01069, Dresden, Germany.
Cell-instructive polymer hydrogels are instrumental in tissue engineering for regenerative therapies. Implementing defined and selective responsiveness to external stimuli is a persisting challenge that critically restricts their functionality. Addressing this challenge, this study introduces a versatile, modular hydrogel system composed of four-arm poly(ethylene glycol)(starPEG)-peptide and glycosaminoglycan(GAG)-maleimide conjugates.
View Article and Find Full Text PDFGenes Cells
January 2025
Advanced Biological Information Research Division, INAMORI Frontier Research Center, Kyushu University, Fukuoka, Japan.
Preimplantation embryonic development is orchestrated by dynamic changes in the proteome and transcriptome, regulated by mechanisms such as maternal-to-zygotic transition. Here, we employed label-free quantitative proteomics to comprehensively analyze proteome dynamics from germinal vesicle oocytes to blastocysts in mouse embryos. We identified 3490 proteins, including 715 consistently detected across all stages, revealing stage-specific changes in proteins associated with translation, protein modification, and mitochondrial metabolism.
View Article and Find Full Text PDFMol Nutr Food Res
January 2025
Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.
Scope: Alzheimer's disease (AD) is the most prevalent form of dementia, lack of effective therapeutic interventions. In this study, we investigate the impact of intermittent fasting (IF), an alternative strategy of calorie restriction, on cognitive functions and AD-like pathology in a transgenic mouse model of AD.
Methods And Results: APP/PS1 mice at 6 months were randomly allocated to two dietary groups: one receiving ad libitum (AL) feeding and the other undergoing IF for 1 month.
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