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| http://dx.doi.org/10.5021/ad.24.008 | DOI Listing |
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CYR61 Is Overexpressed in Human Melanoma Tissue and Promotes Melanoma Cell Survival and Proliferation Through Its Binding Ligand Integrin β3 .
Ann Dermatol
December 2024
Department of Dermatology, Soonchunhyang University Hospital, Seoul, Korea.
Centromere protein K enhances the activation of YAP1/TAZ signal cascade to drive the progression of clear cell renal cell carcinoma.
Toxicol Appl Pharmacol
January 2025
Department of Urinary Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi' an 710004, China. Electronic address:
Centromere protein K (CENPK) is a newly identified malignancy-related gene that exhibits differential expression in various cancers and plays a crucial role in carcinogenesis. However, it remains uncertain whether CENPK is involved in clear cell renal cell carcinoma (ccRCC). This work aimed to unveil the expression, clinical significance, biological functions, and regulatory mechanisms of CENPK in ccRCC.
View Article and Find Full Text PDFThe E3 ubiquitin ligase RNF6 facilitates the progression of cervical cancer by inhibiting the Hippo/Yap pathway.
Cell Div
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Department of Oncology, Jiangxi Maternal and Child Health Hospital, 318 Bayi Road, 330006, Nanchang, Jiangxi Province, P.R. China.
Purpose: Cervical cancer (CC), a significant global health threat, necessitates comprehensive understanding for improved therapeutic interventions. Many research indicates that dysregulation of the Hippo-YAP1 pathway leads to uncontrolled proliferation and invasion of tumor cells, promoting the progression of various cancers. This article aims to elucidate the role of RNF6 in CC and its regulation of the Hippo-YAP1 signaling pathway.
View Article and Find Full Text PDFTargeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis.
J Orthop Translat
July 2024
State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Background: The mechanism by which chondrocyte senescence aggravate OA progression has not yet been well elucidated. The aim of this study was to investigate the chondrocyte senescence related gene biosignatures in OA, and to analyze on the underlying mechanisms of senescence in OA.
Materials And Methods: We intersected osteoarthritis dataset GSE82107 from GEO database and senescence dataset from CellAge database of human senescence-associated genes based on genetic manipulations experiments plus gene expression profilin, and screened out 4 overlapping genes.
CYR61 is Involved in Neonatal Hypoxic-ischemic Brain Damage Via Modulating Astrocyte-mediated Neuroinflammation.
Neuroscience
August 2024
Department of Oncology, the First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
The activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in astrocytes has been found in the hypoxic-ischemic brain damage (HIBD) model. Cysteine rich angiogenic inducer 61 (CYR61) is secreted by reactive astrocytes. However, the effects of CYR61 on HIBD and its related mechanisms remain unclear.
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