AI Article Synopsis
- Epigenetic heterogeneity plays a key role in how biological systems function and can influence tumor behavior and resistance to treatments.
- The authors introduce a new tool called epiCHAOS, which measures variations in epigenetic traits between individual cells, regardless of their grouping.
- After testing its effectiveness on simulated data, epiCHAOS is shown to reveal important insights into developmental and cancer-related characteristics, enhancing our understanding of single-cell epigenomics in these contexts.
Article Abstract
Epigenetic heterogeneity is a fundamental property of biological systems and is recognized as a potential driver of tumor plasticity and therapy resistance. Single-cell epigenomics technologies have been widely employed to study epigenetic variation between-but not within-cellular clusters. We introduce epiCHAOS: a quantitative metric of cell-to-cell heterogeneity, applicable to any single-cell epigenomics data type. After validation in synthetic datasets, we apply epiCHAOS to investigate global and region-specific patterns of epigenetic heterogeneity across diverse biological systems. EpiCHAOS provides an excellent approximation of stemness and plasticity in development and malignancy, making it a valuable addition to single-cell cancer epigenomics analyses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613708 | PMC |
| http://dx.doi.org/10.1186/s13059-024-03446-w | DOI Listing |
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