Where do novel research questions come from? We suggest that identifying key computational problems and comparing solutions across domains can be one source. We exemplify this by looking at perception and action and outline how findings from one domain may generate novel research avenues in the other.
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| http://dx.doi.org/10.1016/j.neubiorev.2024.105966 | DOI Listing |
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Perspectives of persons with mild cognitive impairment, caregivers and healthcare professionals on computer-assisted cognitive training: A multi-perspective qualitative study.
Geriatr Nurs
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School of Nursing, Jilin University, Changchun, Jilin, 130021, China. Electronic address:
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Biophys Chem
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Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Computational Biophysics Research Group, RIKEN Center for Computational Science, 7-1-26 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, 1-6-5 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Membrane potential is essential in biological signaling and homeostasis maintained by voltage-sensitive membrane proteins. Molecular dynamics (MD) simulations incorporating membrane potentials have been extensively used to study the structures and functions of ion channels and protein pores. They can also be beneficial in designing and characterizing artificial ion channels and pores, which will guide further amino acid sequence optimization through comparison between the predicted models and experimental data.
View Article and Find Full Text PDFReligion as a Functional Equivalent of Medicine: Religious Experiences of Family Caregivers of People with Chronic Illnesses in Addis Ababa, Ethiopia.
J Relig Health
January 2025
Department of Sociology, Addis Ababa University, Addis Ababa, Ethiopia.
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View Article and Find Full Text PDFBasic Science and Pathogenesis.
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University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Background: Accumulating evidence has shown the neuroprotective effects of estrogen on cognition function, for example delaying the cognitive deterioration in patients with Alzheimer's disease (AD). However, the clinical usage of estrogen in AD remains controversial. The cytochrome P450 aromatase encoded by CYP19A1, is a key enzyme catalyzing the C19 androgen conversion to C18 estrogen, which induces testosterone to estradiol and androstenedione to estrone.
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