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A newly bat-borne hantavirus detected in Seba's short-tailed bats (Carollia perspicillata) in the Brazilian Atlantic Rainforest.
Mem Inst Oswaldo Cruz
December 2024
Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Hantaviroses e Rickettsioses, Rio de Janeiro, RJ, Brasil.
Background: Bat-borne hantaviruses have been identified worldwide but little is known about neotropical bats in the megadiverse biomes of the American continent. Although serological evidence has hinted at hantavirus circulation in Brazil, the scarce number of genomic detection represents a gap to understand viral diversity, prevalence, and ecology of bat-borne hantaviruses.
Objective: We aim to investigate and evaluate the presence and prevalence of bat-borne hantavirus in the Brazilian Atlantic Forest.
Surveillance of Schmallenberg virus in cattle populations in Northeastern Brazil.
Trop Anim Health Prod
December 2024
Federal Rural University of Pernambuco (UFRPE), R. Dom Manuel de Medeiros, s/n - Dois Irmãos, Recife, Pernambuco, 52171-900, Brazil.
The objective of this study was to conduct a serological investigation of Schmallenberg virus (SBV) infection in cattle raised in the State of Alagoas. A total of 460 serum samples from the Agricultural Defense Agency of Alagoas (ADEAL) serum bank were analyzed. These samples were collected from unvaccinated cattle on 100 properties across 99 municipalities in Alagoas, representing the three mesoregions: Agreste, Leste, and Sertão.
View Article and Find Full Text PDFCan antiviral drugs address the treatment challenges of severe fever with thrombocytopenia syndrome? - a systematic meta-analysis.
J Infect Dev Ctries
November 2024
Department of Administrative, Zhoushan Hospital, Zhoushan, China.
Background: Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease with high mortality and severity rates. However, there is no clear treatment plan, specific effective antiviral drugs, or effective vaccine for SFTS. Recent studies have shown that the therapeutic effect of Ribavirin and other commonly used antiviral drugs such as Favipiravir (T-705), on SFTS is still controversial.
View Article and Find Full Text PDFSystemic Clodronate Liposome Treatment for Depletion of Blood-Contacting Phagocytes and Investigation of Their Role in the Control of Bunyavirus Viremia.
Methods Mol Biol
December 2024
Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.
During viral infection, phagocytic cells participate in numerous immunological processes. A common approach to elucidate the specific contributions of phagocytic cells is through direct comparison of viral pathogenesis of phagocyte-depleted and phagocyte-intact animals. Clodronate liposomes are a versatile and simple means of depleting phagocytes in any animal model.
View Article and Find Full Text PDFEfficient Expression of Oropouche Virus Nonstructural Proteins NSs and NSm.
Methods Mol Biol
December 2024
Department of Pathology, The Sealy Institute for Vaccine Sciences, The Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Oropouche fever, a mosquito- or midge-borne emerging zoonotic disease endemic to South and Central America, manifests as a dengue-like acute febrile illness with occasional occurrences of meningitis or meningoencephalitis. The causative agent, Oropouche virus (OROV), belongs to the genus Orthobunyavirus within the family Peribunyaviridae. Its tripartite negative-sense RNA genome comprises small (S), medium (M), and large (L) segments, encoding structural N, Gn/Gc, and L proteins, respectively.
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