Delayed percutaneous intradiscal hydrogel herniation causing neurological injury after minor trauma: illustrative case.

J Neurosurg Case Lessons

Section of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.

Published: December 2024

Background: Percutaneous intradiscal hydrogel injection has been used to treat low-back pain (LBP) due to degenerative disc disease with or without mild radicular pain. Complications from these procedures are underreported. In this case lesson, the authors present a rare case of a patient with herniated intradiscal hydrogel following a minor trauma leading to neurological injury.

Observations: A 36-year-old female who had been previously treated with L4-5 and L5-S1 intradiscal hydrogel injections for LBP presented with painful, progressive right-sided lower-extremity weakness after experiencing a twisting trauma. Cross-sectional imaging results revealed a herniated hydrogel-based disc implant in the spinal canal. She underwent an urgent L4-5 laminectomy for decompression and removal of the herniated implant. A large annular defect was noted. Postoperatively, she had resolution of her right leg pain but experienced persistent right foot drop requiring an ankle-foot orthosis.

Lessons: Herniated intradiscal hydrogel implants can lead to permanent neurological injury. While the risk factors for hydrogel herniation have not been elucidated, they can be related to pre-existing disruptions to the annulus and/or posterior longitudinal ligament, excess volume of hydrogel injection, and insufficient fixation time. Further research is needed to determine the safety and efficacy of this technology. https://thejns.org/doi/10.3171/CASE24394.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11616144PMC
http://dx.doi.org/10.3171/CASE24394DOI Listing

Publication Analysis

Top Keywords

intradiscal hydrogel
20
percutaneous intradiscal
8
hydrogel herniation
8
neurological injury
8
minor trauma
8
hydrogel injection
8
herniated intradiscal
8
hydrogel
7
intradiscal
5
delayed percutaneous
4

Similar Publications

Background: Percutaneous intradiscal hydrogel injection has been used to treat low-back pain (LBP) due to degenerative disc disease with or without mild radicular pain. Complications from these procedures are underreported. In this case lesson, the authors present a rare case of a patient with herniated intradiscal hydrogel following a minor trauma leading to neurological injury.

View Article and Find Full Text PDF

Biomaterials, such as hydrogels, have an increasingly important role in the development of regenerative approaches for the intervertebral disc. Since animal models usually resist biomaterial injection due to high intradiscal pressure, preclinical testing of the biomechanical performance of biomaterials after implantation remains difficult. Papain reduces the intradiscal pressure, creates cavities within the disc, and allows for biomaterial injections.

View Article and Find Full Text PDF

While mesenchymal stem cell (MSC) shows great potentials in treating intervertebral disc degeneration, most MSC die soon after intradiscal transplantation, resulting in inferior therapeutic efficacy. Currently, bulk hydrogels are the common solution to improve MSC survival in tissues, although hydrogel encapsulation impairs MSC migration and disrupts extracellular microenvironment. Cell hydrogel encapsulation has been proposed to overcome the limitation of traditional bulk hydrogels, yet this technique has not been used in treating disc degeneration.

View Article and Find Full Text PDF

Injectable Radiopaque Hyaluronic Acid Granular Hydrogels for Intervertebral Disc Repair.

Adv Healthc Mater

October 2024

Department of Orthopaedic Surgery, McKay Orthopaedic Research Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Injectable hydrogels offer minimally-invasive treatment options for degenerative disc disease, a prevalent condition affecting millions annually. Many hydrogels explored for intervertebral disc (IVD) repair suffer from weak mechanical integrity, migration issues, and expulsion. To overcome these limitations, an injectable and radiopaque hyaluronic acid granular hydrogel is developed.

View Article and Find Full Text PDF
Article Synopsis
  • - The study evaluated the safety and effectiveness of a hydrogel injection (Hydrafil) in 20 patients aged 22-69 with chronic low back pain due to degenerative disc disease that did not respond to regular treatment.
  • - After an average follow-up of 131 days, results indicated significant reductions in pain (from a median score of 7 to 1) and disability (from a median score of 54 to 2) after 6 months.
  • - Although there were 5 serious adverse events, only 4 were linked to the treatment, suggesting that the hydrogel implant is safe and effective in alleviating pain and improving function in these patients.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!