AI Article Synopsis
- Dysregulation of lipid homeostasis leads to the formation of lipid-filled foamy macrophages (FMs) that can help intracellular pathogens survive and cause ongoing infections.
- High levels of the immune-modulatory cytokine IL-10 are linked to the transformation of macrophages into their foamy state, playing a key role in this process.
- The review explores how pathogens manipulate the IL-10-FM interaction to establish infections and suggests targeting this axis for potential new treatments against intracellular infections.
Article Abstract
Dysregulation of lipid homeostasis causes the deposition of lipids in the form of tiny droplets within foamy macrophages (FMs). In FMs, host-derived lipids aid in survival of various intracellular pathogens leading to sustained infection. In several infectious diseases, the transformation of macrophages into a foamy phenotype is linked to the presence of high IL-10, a potent immune-modulatory cytokine. This review aims to understand the role of IL-10 in the signaling events that are crucial in generation of FMs and highlights how various intracellular pathogens targets the IL-10-FM axis for successful establishment of infections. The review also briefly discusses how the IL-10-FM axis can be a target for developing novel therapeutic strategies to prevent intracellular infections.
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| http://dx.doi.org/10.4049/jimmunol.2400033 | DOI Listing |
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