[This corrects the article DOI: 10.1371/journal.pone.0271288.].
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611191 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0315112 | PLOS |
Sci Rep
January 2025
Program in Biochemistry, Mount Holyoke College, South Hadley, MA, 01075, USA.
We have previously developed a transcription-based bacterial three-hybrid (B3H) assay as a genetic approach to probe RNA-protein interactions inside of E. coli cells. This system offers a straightforward path to identify and assess the consequences of mutations in RBPs with molecular phenotypes of interest.
View Article and Find Full Text PDFSci Rep
January 2025
Praxis Dr.Carmine, Etzelstrasse 21, Pfaeffikon SZ, 8808, Switzerland.
Spot-urinary biomarkers are crucial in medical, epidemiological, and environmental studies, but their variability due to hydration levels requires precise dilution adjustments. Traditional methods, like conventional creatinine correction (CCRC), are limited in compensating for variations in urine concentration, causing substantial inconsistencies, particularly at the extremes of the diuresis spectrum. While restricting the creatinine (CRN) range to 0.
View Article and Find Full Text PDFMol Neurobiol
January 2025
Research and Innovation Center, Shanghai Pudong Hospital, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, 200433, China.
Investigating plasma proteomic signatures of dementia offers insights into its pathology, aids biomarker discovery, supports disease monitoring, and informs drug development. Here, we analyzed data from 48,367 UK Biobank participants with proteomic profiling. Using Cox and generalized linear models, we examined the longitudinal associations between proteomic signatures and dementia-related phenotypes.
View Article and Find Full Text PDFMucosal Immunol
January 2025
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh Medical Center Pittsburgh PA USA; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine New Haven CT USA. Electronic address:
Host response aimed at eliminating the infecting pathogen, as well as the pathogen itself, can cause tissue injury. Tissue injury leads to the release of a myriad of cellular components including mitochondrial DNA, which the host senses through pattern recognition receptors. How the sensing of tissue injury by the host shapes the anti-pathogen response remains poorly understood.
View Article and Find Full Text PDFComput Biol Med
January 2025
Department of Computer Science and Engineering, Rajkiya Engineering College, Kannauj, India; Affiliated with Abdul Kalam Technical University(AKTU), Jankipuram Vistar, Lucknow, Uttar Pradesh, 226031, India. Electronic address:
Problem: The most prevalent cancer in women is breast cancer (BC), and effective treatment depends on being detected early. Many people seek medical imaging techniques to help in the early detection of problems, but results often need to be corrected for increased accuracy.
Aim: A new deep learning approach for medical images is applied in the detection of BC in this paper.
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