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Unlabelled: Motivated behaviors are regulated by distributed forebrain networks. Traditional approaches have often focused on individual brain regions and connections that do not capture the topographic organization of forebrain connectivity. We performed co-injections of anterograde and retrograde tract tracers in rats to provide novel high-spatial resolution evidence of topographic connections that elaborate a previously identified closed-loop forebrain circuit implicated in affective and motivational processes.
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Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy.
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Ist Clinic of General Surgery, Arad County Emergency Clinical Hospital, 310158 Arad, Romania.
Sentinel lymph node biopsy (SLNB) has become a method more and more frequently used in loco-regional breast cancer in the initial stages. Starting from the first report on the technical feasibility of the sentinel node method in breast cancer, published by Krag (1993) and Giuliano (1994), the method underwent numerous improvements and was also largely used worldwide. This article is a prospective study that took place at the "SJUPBT Surgery Clinic Timisoara" over a period of 1 year between July 2023 and July 2024, during which 137 underwent sentinel lymph node biopsy (SLNB) based on the current guidelines.
View Article and Find Full Text PDFExogenous insulin does not reduce protein catabolism in pre-diabetic cystic fibrosis patients: A randomized clinical trial.
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Department of Pediatrics, University of Minnesota, Academic Office Building, AOB-120, 2450 Riverside Ave, Minneapolis, Minnesota 55454. Electronic address:
Background: Cystic Fibrosis (CF) patients historically suffered from undernutrition, infection and inflammation. Insulin insufficiency-related protein catabolism further compromised health. We aimed to determine whether insulin improves protein catabolism in CF youth with abnormal glucose tolerance (AGT).
View Article and Find Full Text PDFHeterobivalent Dual-Target Peptide for Integrin-αβ and Neuropeptide Y Receptors on Breast Tumor.
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Mackenzie Evangelical College of Paraná, Mackenzie Presbyterian University, Curitiba 80730-000, Brazil.
Heterodimer peptides targeting more than one receptor can be advantageous, as tumors can simultaneously express more than one receptor type. For human breast cancer, a promising biological target is tumor angiogenesis through αβ integrin expression. Another promising target is Neuropeptide Y receptors, considering YR is overexpressed in 90% of human breast tumors.
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