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DNA damage triggers heritable alterations in DNA methylation patterns in Arabidopsis.
Mol Plant
January 2025
State Key Laboratory of Wheat Improvement, School of Advanced Agricultural Sciences, Peking University, Beijing 100871, China; Beijing Life Science Academy, Beijing 102299, China. Electronic address:
It has been hypothesized that DNA damage has the potential to induce DNA hypermethylation, contributing to carcinogenesis in mammals. However, there is no sufficient evidence to support that DNA damage can cause genome-wide DNA hypermethylation. Here, we demonstrated that DNA single-strand breaks with 3'-blocked ends (DNA 3'-blocks) can not only reinforce DNA methylation at normally methylated loci but also can induce DNA methylation at normally nonmethylated loci in plants.
View Article and Find Full Text PDFCohort study to evaluate the pattern of analgesic prescription in adult patients undergoing ambulatory surgery.
Rev Esp Anestesiol Reanim (Engl Ed)
January 2025
Servicio de Anestesiología y Reanimación, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Departamento de Medicina Legal, Psiquiatría y Patología, Universidad Complutense, Madrid, Spain. Electronic address:
Introduction: Postoperative pain in ambulatory surgery (AS) continues to be a recurrent problem despite anesthetic and surgical advances. Analgesic prescription and follow-up by patients at home may be a determining factor. Our objective was to evaluate analgesic prescription and its impact on the intensity of postoperative pain at 24 h and 7 days in an AS unit.
View Article and Find Full Text PDFA Line of Sight/Non Line of Sight Recognition Method Based on the Dynamic Multi-Level Optimization of Comprehensive Features.
Sensors (Basel)
January 2025
School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China.
With the advent of the 5G era, high-precision localization based on mobile communication networks has become a research hotspot, playing an important role in indoor emergency rescue in shopping malls, smart factory management and tracking, as well as precision marketing. However, in complex environments, non-line-of-sight (NLOS) propagation reduces the measurement accuracy of 5G signals, causing large deviations in position solving. In order to obtain high-precision position information, it is necessary to recognize the propagation state of the signal before distance measurement or angle measurement.
View Article and Find Full Text PDFIndependent genetic strategies define the scope and limits of CDKL5 deficiency disorder reversal.
Cell Rep Med
January 2025
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19102, USA; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19102, USA; The Epigenetics Institute, University of Pennsylvania, Philadelphia, PA 19102, USA. Electronic address:
Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a neurodevelopmental syndrome caused by mutations in the X-linked CDKL5 gene. The early onset of CDD suggests that CDKL5 is essential during development, but post-developmental re-expression rescues multiple CDD-related phenotypes in hemizygous male mice. Since most patients are heterozygous females, studies in clinically relevant female models are essential.
View Article and Find Full Text PDFThe TRIM-NHL RNA-binding protein MEI-P26 modulates the size of Drosophila Type I neuroblast lineages.
Genetics
January 2025
Department of Molecular Genetics, University of Toronto, 661 University Avenue, Toronto, Ontario, Canada M5G 1M1.
The Drosophila TRIM-NHL RNA-binding protein (RBP), MEI-P26, has previously been shown to suppress tumor formation in the germline. Here we show that, in the Drosophila larval central brain, cell-type specific expression of MEI-P26 plays a vital role in regulating neural development. MEI-P26 and another TRIM-NHL RBP, Brain tumor (BRAT), have distinct expression patterns in Type I neuroblast (NB) lineages: While both proteins are expressed in NBs, BRAT is expressed in ganglion mother cells (GMCs) but not neurons whereas MEI-P26 is expressed in neurons but not GMCs.
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