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Synergistic Anxiolytic Effects of Linalool and Sesamol Co-Treatment on Swiss Albino Mice: A Potential GABAergic Intervention.
Synapse
January 2025
Department of Biochemistry & Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
Sesamol (SES) and linalool (LIN) are aromatic compounds that have neuroprotective effects. The main purpose of this study is to evaluate the anxiolytic activity of LIN and SES co-treatment on Swiss albino mice and analyze its possible mechanism through in silico study. In this sense, the mice were given the gamma-aminobutyric acid type A receptors (GABA) agonist diazepam (DZP; 3 mg/kg, p.
View Article and Find Full Text PDFMeasuring Alcohol-Induced Striatal Dopamine Release in Healthy Humans With [C]-Raclopride: A Meta-Analysis.
Synapse
January 2025
Department of Science, De La Salle College, Institute of the Brothers of the Christian Schools, Toronto, Ontario, Canada.
Alcohol consumption is known to affect dopamine (DA) release in the brain, with significant implications for understanding addiction and its neurobiological underpinnings. This meta-analysis examined the effects of acute alcohol administration on striatal DA release in healthy humans as measured with [C]-raclopride positron emission tomography (PET). Oral alcohol administration was associated with a significant reduction in [C]-raclopride binding potential (BP) in the ventral striatum (Cohen's d = -0.
View Article and Find Full Text PDFAntioxidant Activity and DPP-IV Inhibitory Effect of Fish Protein Hydrolysates Obtained from High-Pressure Pretreated Mixture of Rainbow Trout () and Atlantic Salmon () Rest Raw Material.
Mar Drugs
December 2024
Department of Biological Sciences Ålesund, Norwegian University of Science and Technology, 6009 Ålesund, Norway.
The use of fish rest raw material for the production of fish protein hydrolysates (FPH) through enzymatic hydrolysis has received significant interest in recent decades. Peptides derived from fish proteins are known for their enhanced bioactivity which is mainly influenced by their molecular weight. Studies have shown that novel technologies, such as high-pressure processing (HPP), can effectively modify protein structures leading to increased biological activity.
View Article and Find Full Text PDFOn the potential benefits of wide dynamic range compression for workers in loud environments: a scoping literature review.
Int J Occup Saf Ergon
December 2024
École de technologie supérieure (ÉTS), Université du Québec, Canada.
This literature review investigates the application of wide dynamic range compression (WDRC) to enhance hearing protection and communication among workers in a noisy environment. Given the prevalence of noise-induced hearing loss, there is a major need to provide workers, with or at risk of hearing loss, with a solution that not only protects their hearing but also facilitates effective communication. WDRC, which amplifies softer sounds while limiting louder sounds, appears a promising approach.
View Article and Find Full Text PDFBacteriophage as a novel therapeutic approach for killing multidrug-resistant ST131 clone.
Front Microbiol
December 2024
Department of Biomedical Science, The Graduate School, Kyungpook National University, Daegu, Republic of Korea.
The emergence of the multidrug-resistant (MDR) ST131 clone has significantly impacted public health. With traditional antibiotics becoming less effective against MDR bacteria, there is an urgent need for alternative treatment options. This study aimed to isolate and characterize four lytic phages (EC.
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