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A New Bis-Urea Based Cage Receptor for Anions: Synthesis, Solid State Structures and Binding Studies. | LitMetric

AI Article Synopsis

  • A novel bis-urea-based cage receptor (L) has been synthesized for anion binding, featuring a macro-bicyclic structure with two ureido groups designed for enhanced interaction with anions.
  • The receptor effectively binds various anion guests (G), including spherical anions like chloride (Cl) and V-shaped anions like acetate (AcO), primarily through hydrogen bonding at the ureido moieties.
  • NMR experiments reveal that L forms 1:1 and 1:2 adducts with Cl and AcO, demonstrating stronger interactions with more complex carboxylate anions, like norfloxacin (Nor), and solid-state crystal structures confirmed the nature of these interactions.

Article Abstract

The synthesis and characterization of a novel bis-urea-based cage receptor for anions (3S,15S)-3,15,20,25-tetramethyl-1,4,6,12,14,17,20,25-octaazatricyclo[15.5.5.17.11]octacosa-7(28),10-diene-2,5,13,16-tetraone (L) is reported. L is a macro-bicyclic ligand built on the 1,7-dimethyl-1,4,7,10-tetraazacyclododecane scaffold to obtain a cage topology in which two ureido moieties have been inserted as binding sites for anions. L can interact with anion guests (G) via H-bonding; in particular, it binds both spherical (Cl) and V-shaped anions (AcO) as well as more complex carboxylate anions, such as the norfloxacin (Nor). NMR experiments highlight that the interaction between L and G mainly occurs at the ureido moieties. L forms L-G adducts of 1 : 1 ([LG]) and 1 : 2 ([LG]) stoichiometry with Cl and AcO. Otherwise, in the case of Nor only the formation of the [LG] complex is observed. L shows higher formation constants values for [LAcO] (2.9) and [LNor] (3.6) than [LCl] suggesting a stronger interaction with the carboxylate anions. In the solid state, three crystal structures of the HL⋅G species were obtained (G=Cl, AcO, ClO ) highlighting the H-bonding interaction between the chloride, acetate or perchlorate anions and the -NH functions of the ureido fragment. The comparison between the two parent open chain receptors (Lb-c) and L has been reported and discussed.

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Source
http://dx.doi.org/10.1002/asia.202401258DOI Listing

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