Objective: Postoperative junctional ectopic tachycardia (JET) is usually a self-limiting condition; however, when combined with atrioventricular dissociation and postoperative ventricular dysfunction, it may increase morbidity and mortality. This study aimed to determine the overall incidence of JET following congenital heart surgery, to identify patient and procedure-related risk factors, and to evaluate the clinical impact of JET on outcomes.
Methods: The records of 2,814 patients who underwent cardiac surgery over a five-year period were reviewed retrospectively to identify those with JET. For each patient diagnosed with JET, two controls who underwent surgery during the same period were selected to compare possible risk factors and outcomes.
Results: The incidence of JET following congenital heart surgery was 2.66% in this large cohort. Univariate analyses revealed statistically significant associations between JET and factors such as young age, small body weight, high vasoactive inotropic score, operations involving the ventricular septum, surgical complexity score, increased cardiopulmonary bypass time, delayed sternal closure, extracorporeal membrane oxygenation (ECMO) requirement, and increased risk of postoperative JET. In multivariate analysis only the association between surgeries involving the ventricular septum, ECMO requirement, and increased risk of JET persisted. Compared to controls, patients with JET experienced prolonged intubation times, longer stays in the intensive care unit and hospital, more frequent unplanned re-interventions, and higher mortality rates.
Conclusion: Junctional ectopic tachycardia can lead to serious hemodynamic consequences in patients following congenital heart surgery and is associated with poorer clinical outcomes. Both patient and procedure-related factors contribute to the overall risk of developing JET. Identifying associations and predictors of JET can help improve patient outcomes.
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http://dx.doi.org/10.5543/tkda.2024.77449 | DOI Listing |
Pediatr Cardiol
January 2025
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, The Heart Institute, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Cardiac-Urogenital Syndrome (CUGS) is a recently identified genetic disease characterized by urogenital, diaphragmatic, ophthalmic, and cardiac abnormalities caused by heterozygous pathogenic variants in the Myelin Regulatory Factor (MYRF) gene. The complete spectrum of disease characteristics and prevalence is not yet defined. This report documents the first known cases of anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) in MYRF-associated Cardiac-Urogenital Syndrome (MYRF-CUGS).
View Article and Find Full Text PDFZhonghua Yi Xue Yi Chuan Xue Za Zhi
January 2025
Department of Obstetrics and Gynecology, the Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Objective: To explore the genetic characteristics of a Chinese pedigree with rare mosaic 11q partial duplication and its pathogenetic mechanisms.
Methods: A pedigree which underwent prenatal diagnosis at Wenzhou Central Hospital between September 25, 2015 and November 30, 2023 was selected for the study. Clinical data were collected from the pedigree.
BMJ Case Rep
January 2025
Neonatology, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, Maharashtra, India
Arteriovenous malformations (AVMs) are rare congenital vascular malformations with associated morbidities. We describe a neonatal case of upper limb high-flow AVM presenting with upper limb soft tissue mass and postnatal high-output heart failure. Doppler study suggested high-flow AVM, and later magnetic resonance angiography of the right upper limb confirmed the diagnosis.
View Article and Find Full Text PDFResuscitation
January 2025
Department of Surgery, Division of Congenital Cardiac Surgery, University of Washington, Seattle Children's Hospital, Seattle, WA.
Background: While several studies have reported on outcomes of extracorporeal membrane oxygenation (ECMO) in patients with single ventricle physiology, few studies have described outcomes of extracorporeal cardiopulmonary resuscitation (ECPR) in this unique population. The objective of this study was to determine survival and risk factors for mortality after ECPR in single ventricle patients prior to superior cavopulmonary anastomosis, using a large sample from the Extracorporeal Life Support Organization (ELSO) Registry.
Methods: We included single ventricle patients who underwent ECPR for in-hospital cardiac arrest (IHCA) between January 2012 and December 2021.
J Am Soc Echocardiogr
January 2025
Department of Congenital Heart Disease, Evelina London Children's Hospital, Guy's & St Thomas' NHS Trust, Westminster Bridge Road, London SE1 7EH, UK; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Background: Newborns with transposition of the great arteries (TGA) are at risk of severe hypoxia from inadequate atrial mixing, closure of the arterial duct and/or pulmonary hypertension (PPHN). Acute maternal hyperoxygenation (AMH) might assist in identifying at-risk fetuses. We report pulmonary vasoreactivity to AMH in TGA fetuses and its relationship to early postnatal hypoxia and requirement for emergency balloon atrial septostomy (e-BAS).
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