AI Article Synopsis
- Five new lignanamides and ten known amides were extracted from the roots' chloroform extract, with new compounds identified through NMR and mass spectrometry.
- The absolute configuration of one compound was determined using ECD experiments and quantum mechanical calculations.
- The anti-inflammatory effects of these compounds were tested on macrophages, showing that all reduced nitric oxide levels, while one compound did not significantly affect IL-10 levels, indicating potential anti-inflammatory properties.
Article Abstract
Five new lignanamides (-) and ten known amides (-) were isolated from the chloroform extract of roots. The structures of the new compounds were elucidated via analysis of NMR spectroscopic and mass spectrometry data and known structures by comparison with data from the literature. Compound had its absolute configuration established through ECD experiments, NMR calculations and quantum mechanical calculations. The anti-inflammatory activity of compounds (-) was assessed on RAW 264.7 macrophages. All the tested compounds reduced nitric oxide levels. In the cytokine quantification assays, only compound did not significantly reduce IL-10 levels. Moreover, compounds - and also reduced IL-1β levels. These results suggest the anti-inflammatory potential of these compounds.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603264 | PMC |
| http://dx.doi.org/10.1021/acsomega.4c07336 | DOI Listing |
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