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TULP4 degrades RYBP to enhance DNA damage repair and chemosensitivity of pancreatic ductal adenocarcinoma.
Genes Dis
March 2025
Tianjin Key Laboratory of Epigenetics for Organ Development in Preterm Infants, Tianjin Fifth Central Hospital, Tianjin 300450, China.
Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying Circ-Tulp4 Attenuate Diabetes Mellitus with Nonalcoholic Fatty Liver Disease by Inhibiting Cell Pyroptosis through the HNRNPC/ABHD6 Axis.
Tissue Eng Regen Med
January 2025
Department of Endocrinology, The Second Affiliated Hospital of Shandong First Medical University, Taishan Street Road No.366, Tai'an, 271000, Shandong, China.
Background: Diabetes mellitus with nonalcoholic fatty liver disease (DM-NAFLD) represents a complex metabolic syndrome with significant clinical challenges. This study explores the therapeutic potential and underlying mechanisms of umbilical cord-derived mesenchymal stem cells (UCMSCs)-derived extracellular vesicles (EVs) in DM-NAFLD.
Methods: UCMSCs-EVs were isolated and characterized.
Article Synopsis
- Circular RNAs (circRNAs) are noncoding RNAs, and many have unknown biological functions due to challenges in studying them.
- This study specifically investigated circTulp4, a circRNA found in the brain, by creating a mouse model that lacks circTulp4 while preserving normal mRNA and protein levels.
- The findings show that circTulp4 is essential for proper brain function, influencing neurotransmission and responses to negative stimuli, highlighting the importance of circRNAs in neural regulation.
Role of circRNA in pathogenesis of Alzheimers disease.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
July 2022
Department of Neurology, Second Hospital of Lanzhou University, Lanzhou 730030, China.
Circular RNA (circRNA) is a covalently closed-loop non-coding RNA that exists widely in the transcriptome of eukaryotic cells. It participates in a variety of pathophysiological processes by acting as a microRNA sponge, regulating the level of protein transcription, and interacting with RNA binding proteins. CircRNA is enriched in the cortex, hippocampus, brain white matter, and photoreceptor neurons of aging bodies, and they can be used as a biomarker for neural senescence.
View Article and Find Full Text PDFRETRACTED: circTulp4 functions in Alzheimer’s disease pathogenesis by regulating its parental gene, Tulp4.
Mol Ther
June 2021
Greater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, Guangdong Province, China; Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China. Electronic address:
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).
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