AI Article Synopsis
- Human pericardial fluid (PF) contains biologically active markers that have significant effects on heart-related cellular activities.
- PF can enhance the activity of cardiac fibroblasts, which are important for heart tissue repair, through a specific biological pathway known as the transforming growth factor-β pathway.
- In patients with coronary artery disease, the PF possesses a higher capacity to promote fibrosis compared to those without the disease, indicating a potential area for clinical attention.
Article Abstract
Human pericardial fluid (PF) is a rich reservoir of biologically active markers. The acellular compartment of PF can drive cardiac fibroblast activity in vitro. This process is mediated through the transforming growth factor-β pathway. Of clinical importance, the PF of patients with coronary artery disease has an increased profibrotic capacity compared with the PF of patients without coronary artery disease.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604402 | PMC |
| http://dx.doi.org/10.1016/j.jacbts.2024.06.007 | DOI Listing |
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