Background: Dietary choices are inextricably linked to the incidence of cardiovascular disease (CVD), whereas an optimal dietary pattern to minimize CVD morbidity in high-risk subjects remains challenging.
Methods: We comprehensively assessed the relationship between food consumption frequencies and CVD in 28,979 high-risk subjects. The outcome was defined as the composite of the incidence of major CVD events, including coronary heart disease and stroke. Risk factors associated with CVD were screened through a shrinkage approach, specifically least absolute shrinkage and selection operator (LASSO) regression. Hazard ratios (HRs) for various dietary consumption frequencies were assessed using multivariable Cox frailty models with random intercepts.
Results: Increased egg and seafood consumption were associated with a lower risk of CVD (daily vs little, HR 1.70, 95% confidence interval, CI: 0.79-3.64, = 0.0073 and HR 1.86, 95% CI: 1.24-2.81, = 0.024, respectively). 6 non-food (age, sex, smoke, location, heart ratio, and systolic blood pressure) and 3 food (fruit, egg, and seafood) related risk factors were included in the nomogram to predict 3 and 5-year incidence of CVD. The concordance indexes of the training and validation cohorts were 0.733 (95% CI: 0.725-0.741) and 0.705 (95% CI: 0.693-0.717), respectively. The nomogram was validated using the calibration and time-dependent receiver operating characteristic curves, demonstrating respectable accuracy and discrimination.
Conclusions: Guided by the concept of "food as medicine", this nomogram could provide dietary guidance and prognostic prediction for high cardiac risk subjects in CVD prevention.
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http://dx.doi.org/10.31083/j.rcm2511412 | DOI Listing |
BMC Womens Health
December 2024
Nutrilite Health Institute, 720 Cailun Road, 201203, Shanghai, China.
Background: Primary ovarian insufficiency (POI) is a critical cause of infertility and is increasingly recognized as a complex metabolic disorder. Dietary factors may influence the risk of POI, but causal relationships remain unclear.
Methods: We conducted an MR study using genetic instrumental variables for 83 dietary preferences from the UK Biobank, with the Inverse Variance Weighted method as the primary analysis.
BMC Oral Health
December 2024
Oral Health Initiative, Center for Reproduction and Population Health Studies, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria.
Background: There is no national data on the association between sugar intake and caries experience in Nigeria. This systematic review and meta-analysis aimed to assess the association between sugar intake and caries experience in Nigeria.
Methods: A search was conducted across the PubMed, Web of Science, Scopus, and Embase databases for articles published between January 2001 and March 2023 on the associations between sugar consumption and caries experience.
Pediatr Neonatol
December 2024
Department of Pediatric Surgery, Graduate School of Medicine, The University of Tokyo, Japan. Electronic address:
Background: The treatments and outcomes of pediatric gastroduodenal perforations have rarely been described.
Methods: We retrospectively identified 515 patients aged 28 days to 17 years who were hospitalized for gastroduodenal perforation between July 2010 and March 2021 using a nationwide inpatient database. We compared characteristics, treatments, and outcomes for pediatric gastroduodenal perforation between children aged <7 years (n = 38) and ≥7 years (n = 477).
Cancer Immunol Immunother
December 2024
Department of Surgical Oncology (Urology), Netherlands Cancer Institute, Amsterdam, The Netherlands.
Background: Immune checkpoint inhibitors (ICIs) are an important therapeutic pillar in metastatic urothelial carcinoma (mUC). The occurrence of immune-related adverse events (irAEs) appears to be associated with improved outcomes in observational studies. However, these associations are likely affected by immortal time bias and do not represent causal effects.
View Article and Find Full Text PDFArch Orthop Trauma Surg
December 2024
Università Vita-Salute San Raffaele, Via Olgettina 58, 20132, Milan, Italy.
Introduction: Perioperative steroids administration in total joint arthroplasty gained popularity for pain relief, reduction of postoperative nausea and vomiting (PONV) and enhanced recovery. The purpose of this study is to systematically review and meta-analyze comparative results of prospective randomized trials focused on the effect of systemic steroid administration at different dosages in THA for hip osteoarthritis. The hypothesis is that perioperative systemic steroid administration has a positive impact on postoperative outcomes.
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