AI Article Synopsis
- - The study examines the role of ZNF208, a transcription factor, in breast cancer (BRCA), revealing that its lower expression is linked to poorer patient prognosis and increased promoter methylation levels.
- - Researchers used various databases to analyze gene expression, immune cell interactions, and biological processes related to ZNF208 in BRCA, finding it plays a significant role in inhibiting tumor metastasis and influencing critical signaling pathways.
- - Conclusively, ZNF208 is suggested to function as a tumor suppressor in breast cancer, highlighting its potential as a prognostic marker for patient outcomes.
Article Abstract
Background: Breast cancer (BRCA), the hormone related malignant tumor, is well-known for poor prognosis. ZNF208 mainly acts as a transcription factor in various tumors, and the single nucleotide polymorphisms (SNPs) of ZNF208 are related to telomere length. Nevertheless, its role in breast tumorigenesis is largely unknown.
Methods: We systematically investigated the gene expression, prognostic value, and promoter methylation of in BRCA with Gene Expression Profiling Interactive Analysis (GEPIA) and DNA Methylation Interactive Visualization Database (DNMIVD). Meanwhile, we clarified the association of ZNF208 with tumor-infiltrating immune cells (TICs) from Tumor Immune Estimation Resource (TIMER). Furthermore, we determined the biological process and functional enrichment from Cancer single-cell state atlas (CancerSEA). Finally, we verified our results with prognostic analysis and immunohistochemistry (IHC) assay.
Results: We discovered that ZNF208 was downregulated in breast cancer, and low expression of ZNF208 predicted worse prognosis of BRCA patients. The promoter methylation level of was obviously increased, and ZNF208 was associated with TlCs in BRCA. In addition, ZNF208 could inhibit the metastasis and invasion biological processes, and regulate the MAPK and RAS signaling pathways in BRCA.
Conclusion: Our findings illustrate that ZNF208 can function as a tumor suppressor and predict prognosis of breast cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607762 | PMC |
| http://dx.doi.org/10.1177/11795549241301341 | DOI Listing |
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