Objective: The study aims to determine the correlation between cerebral small vessel diseases (SVDs) and nonarteritic anterior ischemic optic neuropathy (NAION). Additionally, investigate whether NAION raises the risk of an increased total cerebral small vessel disease score (CSVD score) compared to control group without ocular conditions.
Methods: 101 controls without any retinal illness and 61 individuals with NAION were enrolled for this retrospective case control study. Ophthalmic examinations and brain magnetic resonance imaging (MRI) scans were performed on all participants. Data on demographics and clinical characteristics were obtained from hospital medical records. We evaluated and compared the distribution of SVDs and rated the total CSVD score based on SVD indications observed on MRI scans.
Results: SVDs were more frequently in NAION individuals than in control group (82%, < 0.001), and their odds ratio was 4.11 (95%CI: 1.93-8.79, < 0.001). The ordinal logistic regression showed patients in NAION group had 3.08-, 5.66- and 2.90-times higher risk than in control group, at each point of the white matter hyperintensity (WMH) score (95%CI: 1.43-6.79, = 0.003), perivascular spaces (PVS) score (95%CI: 2.31-14.9, < 0.001) and CSVD score (95%CI: 1.32-6.51, = 0.005) respectively. Dyslipidemia presented a higher risk in the presence of SVDs ( = 0.008, OR = 2.31, 95%CI: 1.20-4.44) and WHM score ( = 0.018, OR = 2.22, 95%CI: 1.07-4.70). There was no significant difference between NAION group and controls in sex, age, or other past medical characteristics.
Conclusion: The predictive effect of NAION on SVDs is possible as NAION patients have an increased risk with SVDs. Brain MRI scans and the control of risk factors associated with SVDs should be recommended for individuals who develop NAION.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604583 | PMC |
| http://dx.doi.org/10.3389/fneur.2024.1400452 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Blocking Deoxycytidine Kinase in Activated Lymphocytes Depletes Deoxycytidine Triphosphate Pools and Alters Cell Cycle Kinetics to Yield Less Disease in a Mouse Multiple Sclerosis Model.
Immunology
December 2024
Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, USA.
Autoreactive, aberrantly activated lymphocytes that target myelin antigens in the central nervous system (CNS) are primary drivers of the autoimmune disease multiple sclerosis (MS). Proliferating cells including activated lymphocytes require deoxyribonucleoside triphosphates (dNTPs) for DNA replication. dNTPs can be synthesised via the de novo pathway from precursors such as glucose and amino acids or the deoxyribonucleoside salvage pathway from extracellular deoxyribonucleosides.
View Article and Find Full Text PDFImpact of Small Vessel Disease on Patient Outcomes Following Intravenous Thrombolysis For Acute Ischemic Stroke.
Am J Cardiol
December 2024
Jinan Hospital, 63-1 Lishan Road, Jinan City 250013.
Individual cerebral small vessel disease (SVD) markers independently predict poor prognosis following stroke. However, the impact of a single SVD, especially cumulative SVD burden on outcomes in acute ischemic stroke (AIS) after intravenous thrombolysis remains unclear. This work evaluated the occurrence of small vessel disease (SVD) in AIS patients who were treated with intravenous thrombolytic therapy by using multimodal MRI imaging.
View Article and Find Full Text PDFCholinergic regulation of decision making under risk of punishment.
Neurobiol Learn Mem
December 2024
Department of Psychology, The University of Texas at Austin, Austin TX 78712, United States; Department of Neurology, The University of Texas at Austin, Austin TX 78712, United States; Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin TX 78712, United States. Electronic address:
The ability to choose between options that differ in their risks and rewards depends on brain regions within the mesocorticolimbic circuit and regulation of their activity by neurotransmitter systems. Dopamine neurotransmission in particular plays a critical role in modulating such risk-taking behavior; however, the contribution of other major modulatory neurotransmitters, such as acetylcholine, is not as well-defined, especially for decision making in which the risk associated with more rewarding outcomes involves adverse consequences. Consequently, the goal of the current experiments was to examine how cholinergic signaling influences decision making involving risk of explicit punishment.
View Article and Find Full Text PDFEnabling Electric Field Model of Microscopically Realistic Brain.
Brain Stimul
December 2024
Department of Electrical and Computer Eng., Worcester Polytechnic Inst., Worcester MA USA; Department of Mathematical Sciences, Worcester Polytechnic Inst., Worcester MA USA.
Background: Modeling brain stimulation at the microscopic scale may reveal new paradigms for various stimulation modalities.
Objective: We present the largest map to date of extracellular electric field distributions within a layer L2/L3 mouse primary visual cortex brain sample. This was enabled by the automated analysis of serial section electron microscopy images with improved handling of image defects, covering a volume of 250 × 140 × 90 μm³.
Outcomes of patients receiving urgent palliative radiotherapy for advanced lung cancer: an observational study.
BMC Palliat Care
December 2024
Division of Radiation Oncology, Tom Baker Cancer Centre, 1331 29 Street NW, Calgary, T2N 4N2, Alberta, Canada.
Article Synopsis
- The study evaluates outcomes for patients with advanced lung cancer receiving palliative radiotherapy at the Fast Track Lung Clinic, focusing on treatment responses and survival factors.
- Among 558 patients, a significant 70% showed treatment response, with higher rates linked to better performance status and specific genetic mutations, while those treated for neurological symptoms had lower responses.
- Key factors affecting overall survival included age, performance status, smoking habits, and the presence of metastases, highlighting the complexity of managing advanced lung cancer.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!