Recent advancements in microscopic techniques have significantly progressed, with improvements in fundamental parameters such as resolution, as well as the emergence of novel imaging techniques for measuring cellular information. In this session, six invited speakers introduced recent advancements in super-resolution and advanced microscopy imaging, covering both the development of novel microscopy techniques and their biological applications.
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http://dx.doi.org/10.1007/s12551-024-01228-z | DOI Listing |
PLoS One
January 2025
NCCA, Bournemouth University, Poole, United Kingdom.
Nat Commun
January 2025
Laboratory of High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA.
Optical aberrations hinder fluorescence microscopy of thick samples, reducing image signal, contrast, and resolution. Here we introduce a deep learning-based strategy for aberration compensation, improving image quality without slowing image acquisition, applying additional dose, or introducing more optics. Our method (i) introduces synthetic aberrations to images acquired on the shallow side of image stacks, making them resemble those acquired deeper into the volume and (ii) trains neural networks to reverse the effect of these aberrations.
View Article and Find Full Text PDFSci Rep
December 2024
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, 27599, USA.
A long-standing goal of neuroimaging is the non-invasive volumetric assessment of whole brain function and structure at high spatial and temporal resolutions. Functional ultrasound (fUS) and ultrasound localization microscopy (ULM) are rapidly emerging techniques that promise to bring advanced brain imaging and therapy to the clinic with the safety and low-cost advantages associated with ultrasound. fUS has been used to study cerebral hemodynamics at high temporal resolutions while ULM has been used to study cerebral microvascular structure at high spatial resolutions.
View Article and Find Full Text PDFArtif Intell Med
December 2024
Department of Computer Science and Technology, Cambridge University, Cambridge, United Kingdom. Electronic address:
Electrocardiogram signals play a pivotal role in cardiovascular diagnostics, providing essential information on electrical hearth activity. However, inherent noise and limited resolution can hinder an accurate interpretation of the recordings. In this paper an advanced Denoising Convolutional Autoencoder designed to process electrocardiogram signals, generating super-resolution reconstructions is proposed; this is followed by in-depth analysis of the enhanced signals.
View Article and Find Full Text PDFJACS Au
December 2024
Department of Chemistry and HKU-CAS Joint Laboratory of Metallomics for Health and Environment, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, P.R. China.
Metal ions, either essential or therapeutic, play critical roles in life processes or in the treatment of diseases. Proteins and enzymes are involved in metal homeostasis and the action of metallodrugs. Imaging and identifying these metal-binding proteins will facilitate the elucidation of metal-mediated life processes.
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