On the 28th of June, 2024, we held a session focusing on bacterial motility at the International Union of Pure and Applied Biophysics Congress, held in Kyoto (IUPAB2024). This session was jointly chaired by Professor Seiji Kojima of Nagoya University and Associate Professor Matthew Baker of UNSW Sydney, highlighting significant advancements and discoveries in bacterial cellular mechanisms and motility, with six speakers each from different countries.
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http://dx.doi.org/10.1007/s12551-024-01243-0 | DOI Listing |
ISME J
January 2025
Center for Fundamental and Applied Microbiomics, Biodesign Institue, Arizona State University, Tempe, AZ 85287.
The collective surface motility and swarming behavior of microbes play a crucial role in the formation of polymicrobial communities, shaping ecosystems as diverse as animal and human microbiota, plant rhizospheres, and various aquatic environments. In the human oral microbiota, T9SS-driven gliding bacteria transport non-motile microbes and bacteriophages as cargo, thereby influencing the spatial organization and structural complexity of these polymicrobial communities. However, the physical rules governing the dispersal of T9SS-driven bacterial swarms are barely understood.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, People's Republic of China.
Diabetic wounds are notoriously difficult to heal due to impaired cell repair mechanisms, reduced angiogenesis, and a heightened risk of infection. Fibroblasts play a vital role in wound healing by producing extracellular matrix (ECM) components and various growth factors, but their function is inhibited in diabetic wounds. Chitooligosaccharides (COS), intermediate products of chitosan degradation, have shown efficacy in promoting tissue repair, yet their role in diabetic wound healing remains underexplored.
View Article and Find Full Text PDFInfect Immun
December 2024
Laboratory of Intracellular Bacterial Pathogens, National Centre for Biotechnology (CNB-CSIC), Madrid, Spain.
Type III protein secretion systems (T3SSs) function as multiprotein devices that span the envelope of Gram-negative bacteria using the peptidoglycan (PG) layer as scaffold. This spatial arrangement explains why modifications in PG structure can alter T3SS activity. In incorporation of non-canonical D-amino acids in the PG was shown to decrease the activity of the T3SS encoded by the pathogenicity island-1 (SPI-1) without affecting other T3SS, like the flagellum apparatus.
View Article and Find Full Text PDFCommun Biol
December 2024
Yunnan Provincial Key Laboratory of Animal Nutrition and Feed, Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.
Flagella are essential for biofilm formation, adhesion, virulence, and motility. In this study, the deletion of argR resulted in defects in flagellar synthesis and reduced motility, nevertheless, the underlying mechanism by which ArgR regulated bacterial motility remained unclear. ChIP-Seq and RNA-Seq analysis revealed that ArgR regulated the expression of flagellar genes, concluding two-component system flrBC and multitudinous flagellar structure genes.
View Article and Find Full Text PDFEur J Clin Microbiol Infect Dis
December 2024
Infection and Inflammation, Department of Biotechnology, School of Integrative Biology, Central University of Tamil Nadu, Thiruvarur, Tamil Nadu, 610 005, India.
Purpose: Acinetobacter baumannii (A. baumannii) is an emerging global public health threat owing to its ability to form biofilms. Here, we evaluated 3-hydroxybenzoic acid (3-HBA), a promising organic compound, for its ability to disrupt biofilm formation and virulence attributes in clinical isolates of A.
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