Myasthenia gravis (MG) is an antibody-mediated disorder that disrupts postsynaptic acetylcholine receptors with consequent fatigable weakness, bulbar symptoms, and respiratory fragility. MG patients can be challenging to manage during open abdominal surgery given the unpredictable efficacy of neuromuscular and reversal agents and the risk of precipitating an MG crisis. Regional neuraxial anesthesia eliminates the need for these agents and endotracheal intubation. Here, we report the case of a 66-year-old male with a history of advanced MG, vasovagal episodes with bradycardia and asystolic arrest, and complicated diverticulitis who underwent an uncomplicated open sigmoid colectomy achieved with epidural anesthesia-analgesia. Neuraxial anesthesia can be considered and further investigated as an effective approach in optimizing high-risk patients undergoing open laparotomy for colorectal surgical care.
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http://dx.doi.org/10.7759/cureus.72842 | DOI Listing |
J Pathol
January 2025
Department of Clinical Bio-resource Research and Development, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Spread through air spaces (STAS) is a histological finding of lung tumours where tumour cells exist within the air space of the lung parenchyma beyond the margin of the main tumour. Although STAS is an important prognostic factor, the pathobiology of STAS remains unclear. Here, we investigated the mechanism of STAS by analysing the relationship between STAS and polarity switching in vivo and in vitro.
View Article and Find Full Text PDFCureus
December 2024
Upper Gastrointestinal Surgery, North Manchester General Hospital, Manchester, GBR.
Non-Meckel small bowel diverticula, particularly ileal diverticula, are rare, especially when incarcerated within an inguinal hernia sac. This case involves an 80-year-old man who presented with a newly noticed tender, irreducible lump in his left groin, accompanied by symptoms of bowel obstruction such as inability to pass flatus and vomiting. His medical history included a previous right inguinal hernia repair.
View Article and Find Full Text PDFCureus
December 2024
Comprehensive Colorectal Center, Department of Surgery, Children's Mercy Kansas City, Kansas City, USA.
Long-segment Hirschsprung disease (HSCR) presents significant challenges in surgical management, often requiring extensive bowel mobilization and creative techniques to achieve tension-free anastomosis. Colonic derotation offers a viable solution for preserving bowel length and maintaining the ileocecal valve, which is crucial for postoperative bowel function. The procedure involves extensive colonic mobilization and strategic vascular divisions of the right and middle colic vessels while preserving the ileocolic and marginal arteries, followed by a 180° counterclockwise rotation of the colon around the ileocolic vascular axis.
View Article and Find Full Text PDFChin J Cancer Res
December 2024
Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Objective: Colorectal cancer (CRC) surgeries can be performed using either laparoscopic or open laparotomy approaches. However, the long-term outcomes based on tumor location and age remain unclear. This study compared the long-term outcomes of laparoscopic and laparotomy surgeries in patients with CRC, focusing on tumor location and age to identify suitable subgroups and determine an optimal cut-off age.
View Article and Find Full Text PDFOpen Med (Wars)
January 2025
Imaging Department, Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao, 266011, China.
Objectives: This study aims to assess the potential mechanism of rutin to treat triple-negative breast cancer (TNBC) based on network pharmacology followed by experiments.
Methods: The potential rutin targets were predicted, and the DisGeNET database was used to obtain the disease targets. The intersection targets were identified with Venny 2.
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