In this short paper, I respond to Keith Raymond Harris' paper "Synthetic Media, The Wheel, and the Burden of Proof". In particular, I examine his arguments against two prominent approaches employed to deal with synthetic media such as deepfakes and other GenAI content, namely, the "reactive" and "proactive" approaches. In the first part, I raise a worry about the problem Harris levels at the reactive approach, before providing a constructive way of expanding his worry regarding the proactive approach.
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http://dx.doi.org/10.1007/s13347-024-00828-7 | DOI Listing |
Angew Chem Int Ed Engl
January 2025
Department of Chemistry, Brown University, Providence, Rhode Island 02912, United States.
Despite major progress in the investigation of boron cluster anions, direct experimental study of neutral boron clusters remains a significant challenge because of the difficulty in size selection. Here we report a size-specific study of the neutral B cluster using threshold photoionization with a tunable vacuum ultraviolet free electron laser. The ionization potential of B is measured to be 8.
View Article and Find Full Text PDFPLoS One
January 2025
Academic Unit for Ageing & Stroke Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, United Kingdom.
Background: Understanding recovery is important for patients with stroke and their families, including how much recovery is expected and how long it might take. These conversations can however be uncomfortable for stroke unit staff, particularly when they involve breaking bad news. This study aimed to begin development of a novel complex intervention to improve conversations about recovery on stroke units.
View Article and Find Full Text PDFBiomedicines
December 2024
Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Background/objectives: The enzyme ubiquitin-specific protease 44 (USP44) is a deubiquitinating enzyme with identified physiological roles as a tumor suppressor and an oncogene. While some binding partners and substrates are known for USP44, the identification of other interactions may improve our understanding of its role in cancer. We therefore performed a proximity biotinylation study that identified products of several known cancer genes that are associated with USP44, including a novel interaction between BRCA2 and USP44.
View Article and Find Full Text PDFCureus
November 2024
Department of Emergency Medicine, University of British Columbia, Vancouver, CAN.
Resident physicians often work extended-duration work shifts (EDWSs) exceeding 16 hours. EDWSs are associated with fatigue, workplace errors, mental health problems, and motor vehicle incidents. A 2019 systematic review reported that resident physicians had an increased risk of motor vehicle collisions (MVCs) and of falling asleep at the wheel after EDWSs.
View Article and Find Full Text PDFJ Nutr Biochem
December 2024
Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. Electronic address:
Poor intrauterine environments increase the prevalence of chronic metabolic diseases in offspring, whereas maternal exercise is an effective measure to break this vicious intergenerational cycle. Placenta is increasingly being studied to explore its role in maternal-fetal metabolic cross-talk. The association between placental miRNA and offspring development trajectories has been established, yet the specific role and mechanism thereof in maternal exercise-induced metabolic protection remain elusive.
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