Cult Health Sex
Justice for Sisters, Kuala Lumpur, Malaysia.
Published: December 2024
Despite growing international criticism of actions and efforts to change sexual orientation and gender identity, such efforts remain prevalent in Malaysia. Using data from a nationwide community-based survey, this study examined the prevalence of these efforts amongst LGBT+ adults and the association between exposure to them and mental health outcomes. Participants ( = 521) completed an online survey assessing exposure to efforts to change their sexual orientation and/or gender identity, internalised LGBT-phobia, negative future expectations, and several mental health variables. Just under sixty-four percent ( = 333) of participants reported having experienced change efforts, with the most common perpetrators being family members, friends and religious organisations or people. Recent (past year) and past exposure to change efforts (over one year ago) were each associated with significantly higher odds of suicidal ideation, non-suicidal self-injury, and suicide attempts. Participants with recent exposure to change efforts also reported elevated internalised LGBT-phobia and negative future expectations compared to those who lacked such experience. A content analysis of participants' open-ended responses documented the perceived impact of change efforts on proximal stressors and mental health and wellbeing. Recommendations are made for national authorities and healthcare bodies to ban efforts to change sexual orientation and gender identity in Malaysia.
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http://dx.doi.org/10.1080/13691058.2024.2424225 | DOI Listing |
Biomark Res
January 2025
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Background And Objective: Esophageal cancer (EC) is the seventh most prevalent cancer globally and the sixth leading cause of cancer-related mortality. This study aimed to provide an updated stratified assessment of rates in EC incidence, mortality, and disability-adjusted life-years (DALYs) from 1990 to 2021 by sex, age, and Socio-demographic Index (SDI) at global, regional, and national levels, as well as to project the future trends of EC both globally and regionally.
Methods: Data about age-standardized rates (ASRs) of incidence (ASIR), mortality (ASDR), probability of death (ASPoD) and DALYs (ASDALYRs) of EC were obtained from the 2021 Global Burden of Disease (GBD) study.
Med Phys
January 2025
Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada.
Background: A stemless plastic scintillation detector (SPSD) is composed of an organic plastic scintillator coupled to an organic photodiode. Previous research has shown that SPSDs are ideally suited to challenging dosimetry measurements such as output factors and profiles in small fields. Lacking from the current literature is a systematic effort to optimize the performance of the photodiode component of the detector.
View Article and Find Full Text PDFSurg Endosc
January 2025
Department of Medicine, Surgery and Healthcare Sciences, University of Trieste, Strada Di Fiume 447, 34149, Trieste, Italy.
Background: Climate change poses significant challenges to global health, exacerbated by healthcare systems' carbon footprint and waste generation. Surgical activities contribute to these impacts, necessitating sustainable practices to mitigate environmental harm. This study aims to assess the feasibility and effectiveness of a recycling program in reducing waste, carbon emissions, and disposal costs in the operating rooms (ORs).
View Article and Find Full Text PDFCell Mol Gastroenterol Hepatol
January 2025
Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Electronic address:
Background & Aims: Hepatocellular carcinoma (HCC) frequently undergoes regional chromosomal amplification, resulting in elevated gene expression levels. We aimed to elucidate the role of these poorly understood genetic changes by employing CRISPR activation (CRISPRa) screening in mouse livers to identify which genes within these amplified loci are cancer driver genes.
Methods: We used data from The Cancer Genome Atlas (TCGA) to identify that frequently copy number-amplified and upregulated genes all reside on human Chromosomes 1q and 8q.
Mol Biol Evol
January 2025
Professor Emeritus, School of Biological Sciences, Integrated Cancer Research Center, Georgia Institute of Technology, Atlanta, GA, USA.
The molecular basis of adaptive evolution and cancer progression are both complex processes that share many striking similarities. The potential adaptive significance of environmentally-induced epigenetic changes is currently an area of great interest in both evolutionary and cancer biology. In the field of cancer biology intense effort has been focused on the contribution of stress-induced non-coding RNAs (ncRNAs) in the activation of epigenetic changes associated with elevated mutation rates and the acquisition of environmentally adaptive traits.
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