A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionr5cpm5qgoj0d1s2ipiadmubitciipjrh): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

Investigation of the association between COX-2 polymorphisms and external apical root resorption in orthodontically treated patients. | LitMetric

AI Article Synopsis

  • This study investigates the link between specific genetic variations (SNPs) in the COX-2 gene and the occurrence of external apical root resorption (EARR) in patients after orthodontic treatment.* -
  • Data was collected from 143 orthodontic patients, with analyses focusing on the maxillary central incisors and first mandibular molars, and two SNPs (rs5275 and rs689466) were genotyped using real-time PCR.* -
  • Results show that patients carrying one copy of the G allele for SNP rs5275 have a significant increase in EARR for mandibular molars, suggesting that COX-2 genetic factors may influence the risk of root resorption during orthodontic care.*

Article Abstract

Objective: To evaluate the association between single nucleotide polymorphisms (SNPs) in cyclooxygenase-2 (COX-2) and external apical root resorption (EARR) after orthodontic treatment.

Materials And Methods: This study analyzed the orthodontic records of patients from Regensburg University Hospital and two collaborating private practices. EARR was analyzed in the maxillary central incisors and first mandibular molars using pre- and post-treatment cephalometric and panoramic radiographs, respectively. Genomic DNA was obtained from salivary oral cells. Two SNPs in COX-2, rs5275 (3 prime untranslated region variant) and rs689466 (upstream transcript variant, downstream transcript variant), were genotyped using real-time Polymerase chain reaction (PCR). The linear regression models were fitted to assess the effects of the evaluated SNPs at a significance level of 5%.

Results: A total of 143 biologically unrelated patients (mean age: 13.5 ± 4.5 years) were included in the study. The F-test showed that only the regression for EARR in the mandibular molars in the dominant model for rs5275 G allele had a good fit (F = 3.50, P = 0.034). The model showed that individuals carrying at least one G allele for rs5275 had a 17% increase in EARR in the molars compared to common AA homozygotes (exp(B) = 1.17; 95% CI: 1.04, 1.32; P = 0.010). Although an effect of the G allele (rs5275) was detected, this effect did not explain much of the variability in EARR (adjusted R = 0.04).

Conclusion: The results suggested that patients carrying the polymorphic form of the rs5275 were more likely to have EARR in the mandibular molars; therefore, COX-2 could have an effect on EARR.

Clinical Relevance: The knowledge of the genetic background concerning EARR after orthodontic treatment would aid in clinical practice to screen for associated genetic factors and potentially aid its prevention and management, considering that patients' genetic profiles would soon be available.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00784-024-06064-9DOI Listing

Publication Analysis

Top Keywords

mandibular molars
12
external apical
8
apical root
8
root resorption
8
earr orthodontic
8
transcript variant
8
earr mandibular
8
allele rs5275
8
earr
7
rs5275
5

Similar Publications

Effect of high trimline aligners on distalizing mandibular molars: a three-dimensional finite element study.

Eur J Med Res

December 2024

Urumql DW Innovation InfoTech Co., Ltd., Xinjiang, China.

Objective: The primary focus of this investigation was to evaluate the biomechanical effects of high trimline design aligners on the distalization of mandibular molars, employing three-dimensional finite element analysis (3D-FEA). The study concentrated on aspects such as tooth movement, stress distribution, and anchorage control.

Methods: Utilizing Cone-beam computed tomography (CBCT) data, a detailed 3D geometrical model was constructed for finite element analysis.

View Article and Find Full Text PDF

The Sichuan golden snub-nosed monkey (Rhinopithecus roxellana) is a rare and endangered species endemic to China that occupies a particularly important position in the evolutionary history of Rhinopithecus species. Oral health is a crucial aspect of overall well-being in both humans and nonhuman primates. We review the current limited literature on the dental characteristics and dental pathologies related to the golden snub-nosed monkey, based on skeleton data and morphological evidence.

View Article and Find Full Text PDF

Statement Of The Problem: Considering side effects of non-steroidal anti-inflammatory drugs (NSAIDs), herbal medicine including  might help reduce the pain.

Purpose: The present study aimed to compare the effects of premedication with essential oil of  and ibuprofen on post-endodontic pain.

Materials And Method: The present randomized clinical trial study was conducted on 60 patients with symptomatic irreversible pulpitis of mandibular first or second molars.

View Article and Find Full Text PDF

Rotations of teeth-a systematic review.

Front Oral Health

December 2024

Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.

Background: Rotations are frequently evaluated through various assessment methods of crowding and arch dimension, with relatively few studies discussing the extent or direction of rotations and even fewer addressing the reliability of such assessments. This systematic review aims to comprehensively analyze existing classification systems for rotated teeth and assess rotation in anterior and posterior teeth, its clinical applicability, and its impact on retention and relapse.

Search Methods: Two investigators conducted a comprehensive search in six databases, namely, PubMed, Scopus, Ovid, LILACS, Web of Science, and Cochrane CENTRAL, up to 28 March 2024.

View Article and Find Full Text PDF

Hemangiomas in the head and neck region, especially those that may impact the airway, require special attention perioperatively because of the potential for difficulties with airway management and bleeding control. This case report describes the management of a 31-year-old male with a large hemangioma of the tongue and pharynx undergoing surgical extraction of mandibular third molars under intubated general anesthesia. Despite taking precautions and avoiding traumatizing the hemangioma while securing the airway, massive bleeding occurred during the surgical extractions, which prompted emergent transfer for angiographic embolization and a stay in the intensive care unit until extubation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!