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We evaluated the teratogenic risk associated with exposure to cefditoren pivoxil during the first trimester of pregnancy using the integrated databases of the Toranomon Hospital and the National Center for Child Health and Development. Among 13 599 registered individuals, the analysis included 285 subjects who had taken cefditoren pivoxil during the first trimester of pregnancy. The rates of stillbirth, miscarriage, and elective terminations were 0.4%, 5.6%, and 2.1%, respectively. Among 262 live births, the rates of preterm birth, low birth weight, and major congenital malformations were 4.6%, 5.7%, and 1.2%, respectively. Our results suggest that exposure to cefditoren pivoxil during the first trimester of pregnancy does not significantly increase the risk of adverse pregnancy outcomes and infant outcomes.
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| http://dx.doi.org/10.1111/cga.12588 | DOI Listing |
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- Cefditoren is an oral cephalosporin antibiotic showing strong activity against Streptococcus pneumoniae, but its pharmacokinetics and pharmacodynamics (PK/PD) are not well understood; this study aimed to fill that gap using a mouse model of lung infection.
- The research involved in vitro susceptibility testing and time-kill assays to evaluate cefditoren's effectiveness against S. pneumoniae, leading to calculations of optimal PK/PD parameters needed to reduce bacterial counts significantly.
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