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| http://dx.doi.org/10.1016/j.amjmed.2024.11.024 | DOI Listing |
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Sustained virologic suppression of multidrug-resistant HIV in an individual treated with anti-CD4 domain 1 antibody and lenacapavir.
Nat Med
January 2025
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
The clinical management of people with multidrug-resistant (MDR) human immunodeficiency virus (HIV) remains challenging despite continued development of antiretroviral agents. A 58-year-old male individual with MDR HIV and Kaposi sarcoma (KS) was treated with a new antiretroviral regimen consisting of anti-CD4 domain 1 antibody UB-421 and capsid inhibitor lenacapavir. The individual experienced delayed but sustained suppression of plasma viremia and a substantial increase in the CD4 T cell count.
View Article and Find Full Text PDFViral Load Measurements for Kaposi Sarcoma Herpesvirus (KSHV/HHV8): Review and an Updated Assay.
J Med Virol
December 2024
Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
"When you can measure what you are speaking about, and express it in numbers, you know something about it." is a famous quote attributed to Lord Kelvin. This sentiment puts viral load measurements at the center of virology.
View Article and Find Full Text PDFAn Isolated Kaposi's Sarcoma of the Tongue in an HIV-Negative Patient.
Am J Med
November 2024
Dermatology Department, Fattouma Bourguiba University Hospital, University of Monastir, Monastir, Tunisia.
Seroprevalence and detection of Human herpesvirus-8 (HHV-8) among healthy blood donors residing in Qatar.
J Infect Public Health
December 2024
Biomedical Research Center, QU Health, Qatar University, PO Box 2713, Doha, Qatar. Electronic address:
Background: Human herpesvirus 8 (HHV-8) is a critical causative agent behind Kaposi sarcoma (KS), an oncogenic disease with profound consequences in immunocompromised individuals. Studies suggested HHV-8 seroprevalence in healthy populations is uncommon, but comprehensive investigations within the Middle East region remain scarce. This study aimed to bridge this knowledge gap by meticulously assessing HHV-8 seroprevalence among healthy blood donors in Qatar, leveraging serological methodologies and PCR.
View Article and Find Full Text PDFSevere herpes simplex virus - 1 Kaposi varicelliform eruption and SARS-CoV-2 infection in atopic dermatitis treated with dupilumab.
BMC Infect Dis
November 2024
Department of Dermatology, The First Affiliated Hospital of Chongqing College of Traditional Chinese Medicine, No. 40 Daomenkou St., District Yuzhong, Chongqing, 400011, P.R. China.
Article Synopsis
- A case report discusses a 35-year-old male with a history of atopic dermatitis who developed a severe herpes simplex virus-1 (HSV-1) related skin condition called Kaposi varicelliform eruption (KVE) after a recent SARS-CoV-2 infection.
- The patient's skin condition involved widespread vesicles and pustules that rapidly progressed over four months, and laboratory tests confirmed he was positive for HSV-1 with elevated IgE levels and decreased immune cell counts.
- Treatment with valaciclovir and other medications led to significant improvement, with the skin lesions resolving completely within a week, emphasizing the risk of severe viral eruptions in patients with existing skin conditions following viral infections.
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