AI Article Synopsis
- Phthalates, which are chemicals that disrupt endocrine functions, have been linked to cardiovascular risk factors, particularly during puberty.
- This study examined 101 Dutch adolescents aged 13-15, measuring urinary concentrations of 13 phthalate metabolites along with various health metrics like BMI, cholesterol levels, and hormonal factors.
- Results indicated that higher concentrations of certain phthalates correlated with increased BMI and lipid levels in girls, while boys showed a different association with lower LDL cholesterol.
Article Abstract
Phthalates have been linked to cardiovascular risk factors. Exposure to chemicals with endocrine disrupting properties during the pubertal period can interfere with normal endocrine processes. This study aims to determine whether adolescent urinary concentrations of phthalate metabolites are associated with indices of overweight and cardiovascular risk in 13-15-year-old children. In this Dutch observational cross-sectional cohort study, 101 adolescents were included (mean age 14.4 ± 0.8 years), 55 were boys. The concentrations of 13 phthalate metabolites were measured in morning urine samples. Levels of cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides, fasting insulin, fasting glucose, leptin, and adiponectin were measured. The children's height, weight, waist circumference, hip circumference, and blood pressure were measured. Higher urinary mono-ethyl phthalate concentrations were associated with higher BMI and a larger hip circumference. In girls, higher urinary mono-hydroxy-iso-nonyl phthalate concentrations were associated with higher levels of lipids and obesogenic traits. In boys, higher concentrations of urinary phthalate metabolites were associated with lower LDL-C. The results of this explorative study suggest that higher levels of phthalate metabolites are associated with higher levels of lipids and obesogenic traits in 13-15-year-old girls.
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| http://dx.doi.org/10.1016/j.envint.2024.109167 | DOI Listing |
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