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| http://dx.doi.org/10.1016/j.jbc.2024.107975 | DOI Listing |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648214 | PMC |
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Milk Fat Globules: 2024 Updates.
Newborn (Clarksville)
March 2024
Global Newborn Society, Clarksville Maryland, United States of America.
Article Synopsis
- * MFGs feature a unique structure with a lipid core and a membrane rich in bioactive components that aid in energy release and support immune health in developing gastrointestinal tracts.
- * Research suggests MFGs can be enhanced to address specific nutritional deficiencies while also having potential therapeutic benefits for neurodevelopment and defense against infections.
Metabolic phenotypes and vitamin D response in the critically ill: A metabolomic cohort study.
Clin Nutr
November 2024
Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, USA; Division of Renal Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, USA. Electronic address:
Background & Aims: Although vitamin D deficiency is common in critically ill patients, randomized controlled trials fail to demonstrate benefits of supplementation. We aimed to identify distinct vitamin D responsive metabolic phenotypes prior to trial intervention of high-dose vitamin D by applying machine learning clustering method to metabolomics data from the Correction of Vitamin D Deficiency in Critically Ill Patients (VITdAL-ICU) trial.
Methods: In the randomized, placebo-controlled VITdAL-ICU trial, critically ill adults received placebo or high-dose vitamin D.
Genetically predicted HLA-DR+ natural killer cells as potential mediators in the lipid-coronary artery disease/ calcification (CAD/CAC) causal pathway.
Front Immunol
September 2024
Department of Cardiology, Lihuili Hospital Affiliated to Ningbo University, Ningbo University, Ningbo, Zhejiang, China.
Article Synopsis
- - This study investigates how genetics influence the relationship between lipid profiles and coronary artery disease (CAD), using large-scale genetic data to identify causal links and potential treatment targets.
- - Researchers analyzed a total of 179 lipid and 731 immune cell phenotypes, finding 36 lipids with genetic ties to CAD, where 29 are risk factors and 7 are protective factors, including specific triacylglycerols that significantly increase CAD risk.
- - The results also suggest that certain immune cells, particularly HLA DR+ natural killer cells, may play a role in mediating the impact of these lipids on CAD risk, opening avenues for further research on their therapeutic potential.
Association of Altered Plasma Lipidome with Disease Severity in COVID-19 Patients.
Biomolecules
March 2024
Metabolomics and Analytics Centre, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden, The Netherlands.
The severity of COVID-19 is linked to an imbalanced immune response. The dysregulated metabolism of small molecules and bioactive lipids has also been associated with disease severity. To promote understanding of the disease biochemistry and provide targets for intervention, we applied a range of LC-MS platforms to analyze over 100 plasma samples from patients with varying COVID-19 severity and with detailed clinical information on inflammatory responses (>30 immune markers).
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