Plasma exosomes from patients with coronary artery disease promote atherosclerosis via impairing vascular endothelial junctions.

Sci Rep

Key Lab of Medical Molecular Cell Biology of Shanxi Province, Institutes of Biomedical Sciences, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan, 030006, Shanxi, China.

Published: November 2024

The underlying mechanism of vascular endothelial hyperpermeability caused by decrease of endothelial junctions occurring in atherosclerosis remains elusive. Our findings identified that plasma exosomes from patients with stable coronary artery disease (Exo) contain differentially expressed miRNAs that are clustered with genes related to cell junctions, prompting us to investigate the role of Exo in regulating vascular endothelial junctions and to elucidate the underlying mechanisms. Here, we show that Exo markedly impair vascular endothelial junctions via suppressing VE-Cadherin and ZO-1 in endothelial cells in vitro and in vivo, consequently increases endothelial permeability. Critically, exosomal miR-140-3p plays a crucial role in Exo-induced inhibition of ZO-1, and may be an important causative factor in the development of endothelial hyperpermeability during atherosclerosis. Additionally, exosomal miR-140-3p level coordinates with severity of SCAD. Targeting miR-140-3p in circulating exosomes might open novel options for treatment of atherosclerosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608243PMC
http://dx.doi.org/10.1038/s41598-024-81352-8DOI Listing

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