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Prostaglandin E1: Infants With Critical Congenital Heart Defects. | LitMetric

Prostaglandin E1: Infants With Critical Congenital Heart Defects.

Neoreviews

Department of Pediatrics, Division of Neonatology, University of California, Davis Health, Sacramento, CA.

Published: December 2024

AI Article Synopsis

  • Critical congenital heart defects (CHDs) are serious conditions that require surgical or interventional treatment soon after birth, as they can lead to death within 28 days if not managed properly.
  • Improved prenatal screenings and fetal echocardiography have enhanced the early detection of these defects, allowing for better planning and management by specialized healthcare teams.
  • Understanding the unique hemodynamic challenges that each infant with critical CHDs faces during their transition from the womb to life outside is crucial for effective care and management.

Article Abstract

Critical congenital heart defects (CHDs) are life-threatening cardiac lesions requiring cardiac surgery or transcatheter intervention or result in death within 28 days after birth. In infants with critical CHDs, delayed diagnosis and inappropriate management are associated with higher mortality and comorbidities. Antenatal anomaly screening and fetal echocardiography has improved the detection of fetal CHDs, which helps in perinatal management planning with multidisciplinary teams. Even with precision delivery planning, postnatal transition may affect each infant with CHDs differently depending on the variants and severity of the defect. Therefore, it is important to have a thorough understanding of the hemodynamic physiology in infants with a critical CHD during the transition from intrauterine to extrauterine life and alter management accordingly. This review summarizes the care of infants with critical CHDs in the immediate transition period with a focus on cases with distinctive physiology.

Download full-text PDF

Source
http://dx.doi.org/10.1542/neo.25-12-e765DOI Listing

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