AI Article Synopsis
- - Bronchopulmonary dysplasia (BPD) is a lung disease in preterm infants linked to inflammation and high oxygen levels, but the specifics of how these factors affect the body’s metabolites and gut bacteria are still not fully understood.
- - In a study, pregnant rats were given injections to simulate inflammation and then exposed to different oxygen levels after giving birth, showing changes in gut bacteria and metabolites, particularly increases in certain bacteria and 78 altered metabolites related to important metabolic pathways.
- - The results suggest that both antenatal inflammation and prolonged exposure to oxygen may significantly influence gut microbiota and metabolite profiles, pointing to their potential roles in the development of BPD.
Article Abstract
Bronchopulmonary dysplasia (BPD), a chronic lung disease in preterm infants, is associated with inflammation and high oxygen exposure. However, the effects of antenatal inflammation and postnatal extended hyperoxia on the metabolome and microbiome remain unclear. In this study, pregnant rats received lipopolysaccharide or saline injections on gestational day 20 and were exposed to either 21 % or 80 % oxygen for 4 weeks post-birth. Analysis revealed an increase in Firmicutes, Proteobacteria, and Actinobacteria, with a decrease in Bacteroidetes in BPD rats. Metabolomic analysis identified 78 altered metabolites, primarily lipids, enriched in pathways including arginine biosynthesis, sphingolipid metabolism, and primary bile acid biosynthesis in BPD rats. Integration analysis revealed strong correlations between intestinal microbiota and metabolites in BPD rats. These findings underscored the impact of antenatal inflammation and prolonged postnatal hyperoxia on gut microbiota and serum metabolome, suggesting their role in BPD pathogenesis.
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| http://dx.doi.org/10.1016/j.ygeno.2024.110969 | DOI Listing |
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Article Synopsis
- - Bronchopulmonary dysplasia (BPD) is a lung disease in preterm infants linked to inflammation and high oxygen levels, but the specifics of how these factors affect the body’s metabolites and gut bacteria are still not fully understood.
- - In a study, pregnant rats were given injections to simulate inflammation and then exposed to different oxygen levels after giving birth, showing changes in gut bacteria and metabolites, particularly increases in certain bacteria and 78 altered metabolites related to important metabolic pathways.
- - The results suggest that both antenatal inflammation and prolonged exposure to oxygen may significantly influence gut microbiota and metabolite profiles, pointing to their potential roles in the development of BPD.
A rat model establishment of bronchopulmonary dysplasia-related lung & brain injury within 28 days after birth.
BMC Neurosci
November 2024
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Purpose: Lung injury associated with bronchopulmonary dysplasia (BPD) and its related neurodevelopmental disorders have garnered increasing attention in the context of premature infants. Establishing a reliable animal model is essential for delving into the underlying mechanisms of these conditions.
Methods: Newborn rats were randomly assigned to two groups: the hyperoxia-induced BPD group and the normoxia (NO) group.
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