Anxiolytic-like effects of Prolistarina: A bioinspired peptide from the venom of social wasps.

Pathological anxiety is among the most common psychiatric disorders. Despite advancements, predominant pharmacological treatments can lead to physical, chemical, and psychological dependence. Venoms of arthropods are important sources of neuroactive peptides with potential therapeutic applications for the treatment of neurological disorders. In this context, the anxiolytic effects of Prolistarina (PLT), a bioinspired peptide extracted from the venom of the social wasp Synoeca surinama, were evaluated in mice at the Elevated Plus Maze and Open Field tests. Intracerebroventricular infusions of PLT (6 and 2 nmol) were compared to diazepam (DZP; 2 mg/kg, ip) and pentylenetetrazole (PTZ; 30 mg/kg, ip). Both doses of PLT induced an increase in time spent in the open arms, although 6 nmol was significantly lower than DZP. Locomotor activity was not affected by PLT compared to vehicle, but a significant difference between 2 and 6 nmol was observed. Radioligand binding assays with PLT revealed no affinity for diazepam, naloxone or GABA binding sites. These preliminary results indicate an anxiolytic profile of PLT, but furthers studies are warranted to determine the mechanisms thereof.