Background: Many observational studies have shown a close association between gut microbiota and the risk of various duodenal diseases. Therefore, we urgently explore the potential causal relationship between gut microbiota and some duodenal diseases, mainly including duodenal ulcers and duodenitis.
Methods: We conducted Mendelian randomization (MR) studies using genetic instrumental variables for gut microbiota from GWAS and duodenal disease datasets. Causal relationships were examined using multiple MR methods with Bonferroni correction. Bayesian Weighted Mendelian Randomization (BWMR) assessed causal relationships, employing ELBO and weighted data. Reverse MR analysis was conducted on microbiota showing significant causal relationships with duodenal diseases.
Results: Through MR analysis, we identified three gut microbiota that promote the occurrence of duodenal ulcers (family. Coriobacteriaceae: OR = 1.003; 95 % CI = 1.0005-1.0056; p = 0.016, genus.RuminococcaceaeUCG003: OR = 1.006; 95 % CI = 1.002-1.007; p = 0.002, order. Coriobacteriales: OR = 1.003; 95 % CI = 1.0005-1.0056; p = 0.016), one microbiota that inhibits the occurrence of duodenitis (family. Acidaminococcaceae: OR = 0.994; 95 % CI = 0.988-0.999; p = 0.046), and one microbiota that promotes the occurrence of duodenitis (genus.Eubacteriumcoprostanoligenesgroup: OR = 1.006; 95 % CI = 1.0005-1.013; p = 0.033). Further confirmation of the occurrence of duodenal ulcers and the production of family.Coriobacteriaceae and order.Coriobacteriales microbiota was obtained through reverse MR analysis, indicating that the occurrence of duodenal ulcers also promotes the growth of these microbiota.
Conclusion: Our study employs Mendelian randomization techniques to demonstrate a causal relationship between specific gut microbiota and duodenal ulcers and duodenitis. Additionally, our analysis suggests that duodenal ulcer occurrence promotes the growth of certain microbiota, emphasizing the intricate interplay between gut microbiota composition and these diseases.
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http://dx.doi.org/10.1016/j.micpath.2024.107181 | DOI Listing |
Clin Nutr
December 2024
Division of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and School of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:
Background: Trimethylamine N-oxide (TMAO) is a gut microbial metabolite derived from dietary l-carnitine and choline. High plasma TMAO levels are associated with cardiovascular disease and overall mortality, but little is known about the associations of TMAO and related metabolites with the risk of kidney function decline among patients with chronic kidney disease (CKD).
Methods: We prospectively followed 152 nondialysis patients with CKD stages 3-5 and measured plasma TMAO and related metabolites (trimethylamine [TMA], choline, carnitine, and γ-butyrobetaine) via liquid chromatography‒mass spectrometry.
J Vet Intern Med
December 2024
Veterinary Research Scholars Program (VRSP), University of Missouri College of Veterinary Medicine, Columbia, Missouri 65211, USA.
Background: Whereas restoration of fecal consistency after treatment with clioquinol for chronic diarrhea and free fecal water syndrome has been attributed to its antiprotozoal properties, actions of clioquinol on the colonic bacterial microbiota have not been investigated.
Objectives: Characterize the dynamics of fecal microbial diversity before, during, and after PO administration of clioquinol to healthy horses.
Study Design: Experimental prospective cohort study using a single horse group.
Mol Biol (Mosk)
December 2024
Pirogov All-Russia National Research Medical University, Moscow, 117997 Russia.
Obesity is associated with changes in the gut microbiota, as well as with increased permeability of the intestinal wall. In 130 non-obese volunteers, 57 patients with metabolically healthy obesity (MHO), and 76 patients with metabolically unhealthy obesity (MUHO), bacterial DNA was isolated from stool samples, and the 16S rRNA gene was sequenced. The metabolic profile of the microbiota predicted by PICRUSt2 (https://huttenhower.
View Article and Find Full Text PDFGut Microbes
December 2025
Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash, Clayton, Australia.
The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined the crosstalk between gut microbiome, diet, gut health, and CVD. Traditional CVD risk factors (age, BMI, sex, blood pressure) explained < 10% of the proteome variance.
View Article and Find Full Text PDFMicrobiome
December 2024
MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, Liaoning, 116024, China.
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