AI Article Synopsis
- * There is limited research on Siglecs in the context of neurological disorders, despite their importance in the development and repair of the nervous system.
- * This review highlights the immunomodulatory functions of Siglecs in neurological conditions, the impact of dysregulated sialic acid on psychiatric disorders, and the current limitations in therapeutic research.
Article Abstract
The surfaces of various immune cells are rich in glycan chains, including the sialic-acid-binding immunoglobulin-like lectins (Siglecs) family. As an emerging glyco-immune checkpoint, Siglecs have the ability to bind and interact with various glycoproteins, thereby eliciting a series of downstream reactions to modulate the immune response. The impact of Siglecs has been extensively studied in tumor immunotherapy. However, research in neurological disorders and neurological diseases is very limited, and therapeutic options involving Siglecs need further exploration. Siglecs play a crucial role in the development, homeostasis, and repair processes of the nervous system, especially in degenerative diseases. This review summarizes studies on the immunomodulatory role mediated by Siglecs expressed on different immune cells in various neurological disorders, elucidates how dysregulated sialic acid contributes to several psychiatric disorders, and discusses the progress and limitations of research on the treatment of neurological disorders.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.phrs.2024.107531 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analytical review of facial nerve palsy following SARS-CoV-2 vaccination: comprehensive assessment.
Eur Arch Otorhinolaryngol
January 2025
Department of Otolaryngology-Head and Neck Surgery, Temerty Faculty of Medicine, University of Toronto, 6 Queen's Park Crescent West, Suite 120, Toronto, ON, M5S 3H2, Canada.
Purpose: The SARS-CoV-2 vaccination has reduced COVID-19 infection, though facial nerve palsy (FNP) has emerged as a notable side effect of the vaccine. We evaluated the current literature on the clinical presentation and outcomes of FNP related to COVID-19 vaccination.
Methods: A comprehensive search of seven databases was conducted for studies up to January 2023.
The efficacy and safety of nelarabine in relapsed or refractory T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis.
Ann Hematol
January 2025
Department of Research, Medical Research Circle, Goma, 73 Gisenyi, Democratic Republic of the Congo.
T-cell Acute Lymphoblastic Leukemia (T-ALL) is a subtype of acute lymphoblastic leukemia characterized by the proliferation of abnormal T-cell precursors. Nelarabine, a purine analog, has been approved as a targeted therapy for patients with refractory or relapsed T-ALL. This study aims to evaluate the efficacy and safety of Nelarabine, either as monotherapy or in combination with other therapies, in treating T-ALL.
View Article and Find Full Text PDFMustard Gas Induced Corneal Injury Involves Ferroptosis and p38 MAPK Signaling.
Invest Ophthalmol Vis Sci
January 2025
Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri, United States.
Purpose: Sulfur mustard gas (SM) exposure to eyes causes multiple corneal injuries including stromal cell loss in vivo. However, mechanisms mediating stromal cell loss/death remains elusive. This study sought to test the novel hypothesis that SM-induced toxicity to human corneal stromal fibroblasts involves ferroptosis mechanism via p38 MAPK signaling.
View Article and Find Full Text PDFSocial Determinants of Uncorrected Distance and Near Visual Impairment in an Older Adult Population.
Transl Vis Sci Technol
January 2025
Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Purpose: Uncorrected visual impairment (VI) significantly impacts life quality and exacerbates age-related health issues. Social determinants of health (SDOH) are associated with uncorrected VI, but quantitative evidence is limited. This study investigated the link between SDOH and uncorrected VI among aging adults to identify disparities and improve vision care.
View Article and Find Full Text PDFDoes sound symbolism need sound?: The role of articulatory movement in detecting iconicity between sound and meaninga).
J Acoust Soc Am
January 2025
Department of Apparel and Space Design, Kyoto Women's University, Kyoto, Kyoto 605-8501, Japan.
Ever since de Saussure [Course in General Lingustics (Columbia University Press, 1916)], theorists of language have assumed that the relation between form and meaning of words is arbitrary. However, recently, a body of empirical research has established that language is embodied and contains iconicity. Sound symbolism, an intrinsic link language users perceive between word sound and properties of referents, is a representative example of iconicity in language and has offered profound insights into theories of language pertaining to language processing, language acquisition, and evolution.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!