Incorporating an international perspective in the experience and skill-based focus of leadership learning is central to preparing for leadership in the 21 century; a time when the world is increasingly connected across culture, governance, economies, and educational systems. For leadership educators to be more effective, the authors advocate heeding the voices of international students and colleagues, examining the legacy of colonialism, and engaging as humble and curious learners.
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Impact of an institutional antifungal stewardship program on antifungal usage and outcomes in patients with invasive fungal infections.
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Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
Therapeutic and prophylactic use of antifungals is rising continuously. However, lack of awareness of diagnostic and treatment guidelines and limited laboratory modalities are leading to inappropriate use. This study assessed the impact of an institutional antifungal stewardship program on antifungal use practices and patient outcome.
View Article and Find Full Text PDFBackground: Reproductive life planning is key, now that people with cystic fibrosis (pwCF) may live into their 60s. This study explores contraceptive use, pregnancy trends, and whether concomitant cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy reduces contraceptive effectiveness.
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"Mechanical Integrity Assessment of Polymethylmethacrylate Bone Cement Incorporating Local Anesthetics: Implications for Joint Arthroplasty".
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January 2025
Hospital Clínic Barcelona, Department of Orthopaedic Surgery and Traumatology. Villarroel, 170. 08036 Barcelona, Spain.
Background: Effective management of postsurgical pain following arthroplasty remains a challenge, lacking a definitive gold standard. As most knee and hip arthroplasties are cemented or hybrid, we used the property of bone cement as a drug carrier and added powdered local anesthetics (lidocaine hydrochloride and bupivacaine hydrochloride) to the polymethylmethacrylate (PMMA) as analgesics. However, the addition of drugs to bone cement may compromise its mechanical properties, necessitating a thorough analysis.
View Article and Find Full Text PDFThe Role of Sex and Gender in Acute Kidney Injury - Consensus Statements from the 33 Acute Disease Quality Initiative.
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Department of Critical Care, King's College London, Guy's & St Thomas' Hospital, London, UK.
Sex differences exist in acute kidney injury (AKI), and the role that sex and gender play along the AKI care continuum remains unclear. The 33 Acute Disease Quality Initiative meeting evaluated available data on the role of sex and gender in AKI and identified knowledge gaps. Data from experimental models, pathophysiology, epidemiology, clinical care, gender, social determinants of health, education, and advocacy were reviewed.
View Article and Find Full Text PDFLipid core-chitosan shell hybrid nanoparticles for enhanced oral bioavailability of sorafenib.
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College of Pharmacy, Institute of Pharmaceutical Sciences and Technology, Hanyang University ERICA, Ansan 15588, Republic of Korea. Electronic address:
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