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Frequency-sensitive cell membrane dynamics under ultrasonic stimulation.
Biophys J
January 2025
State Key Laboratory of Mechanics and Control for Aerospace Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, P.R. China; MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, P.R. China. Electronic address:
Multi-modal sensing with integrated machine learning to differentiate specific leukocytes targeted by electrically sensitive hybrid particles.
Biosens Bioelectron
December 2023
Department of Biomedical Engineering, Rutgers, the State University of New Jersey, Piscataway, NJ, 08854, USA; Department of Electrical and Computer Engineering, Rutgers, the State University of New Jersey, Piscataway, NJ, 08854, USA; Global Health Institute, Rutgers, the State University of New Jersey, New Brunswick, NJ, 08901, USA. Electronic address:
The growing need for personalized, accurate, and non-invasive diagnostic technology has resulted in significant advancements, from pushing current mechanistic limitations to innovative modality developments across various disease-related biomarkers. However, there still lacks clinical solutions for analyzing multiple biomarkers simultaneously, limiting prognosis for patients suffering with complicated diseases or comorbidities. Here, we conceived, fabricated, and validated a multifrequency impedance cytometry apparatus with novel frequency-sensitive barcoded metal oxide Janus particles (MOJPs) as cell-receptor targeting agents.
View Article and Find Full Text PDFEffect of Tensile Frequency on the Osteogenic Differentiation of Periodontal Ligament Stem Cells.
Int J Gen Med
July 2022
Department of Stomatology, First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, 710000, People's Republic of China.
Purpose: The role of periodontal ligament stem cells (PDLSCs) in mediating osteogenesis involved in orthodontic tooth movement (OTM) is well established. However, various relevant in vitro studies vary in the frequency of tension. The effect of tensile frequency on the mechanotransduction of PDLSCs is not clear.
View Article and Find Full Text PDFShort term depression, presynaptic inhibition and local neuron diversity play key functional roles in the insect antennal lobe.
J Comput Neurosci
May 2020
Institute of Systems Neuroscience, National Tsing Hua University, Hsinchu, 30013, Taiwan.
As the oldest, but least understood sensory system in evolution, the olfactory system represents one of the most challenging research targets in sensory neurobiology. Although a large number of computational models of the olfactory system have been proposed, they do not account for the diversity in physiology, connectivity of local neurons, and several recent discoveries in the insect antennal lobe, a major olfactory organ in insects. Recent studies revealed that the response of some projection neurons were reduced by application of a GABA antagonist, and that insects are sensitive to odor pulse frequency.
View Article and Find Full Text PDFEffects of sympatho-vagal interaction on ventricular electrophysiology and their modulation during beta-blockade.
J Mol Cell Cardiol
February 2020
Cardiology group, Department of Cardiovascular Sciences, University of Leicester, UK; University Hospitals of Leicester NHS Trust, Leicester, UK; NIHR Leicester Biomedical Research Centre, Leicester, UK. Electronic address:
Aims: The effects of sympatho-vagal interaction on heart rate (HR) changes are characterized by vagal dominance resulting in accentuated antagonism. Complex autonomic modulation of ventricular electrophysiology may exert prognostic arrhythmic impact. We examined the effects of concurrent sympathetic (SNS) and vagus (VNS) nerve stimulation on ventricular fibrillation threshold (VFT) and standard restitution (RT) in an isolated rabbit heart preparation with intact dual autonomic innervation, with and without beta-blockade.
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