AI Article Synopsis
- The study aimed to determine whether chronic rhinosinusitis (CRS) influenced the risk of contracting COVID-19 by comparing CRS patients who had sinus surgery and a matched non-CRS control group.
- Findings revealed no significant association between CRS, regardless of its type (with or without nasal polyps), and the likelihood of COVID-19 infection.
- The research concluded that CRS did not act as a risk or protective factor for COVID-19, with additional insights on olfactory abilities varying between CRS subtypes.
Article Abstract
Background: There are various views in the literature regarding the influence of chronic rhinosinusitis (CRS) as a comorbidity on the occurrence of COVID-19 disease.
Objective: Did CRS prevent or promote infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the coronavirus pandemic?
Materials And Methods: We conducted a retrospective case-control study with 252 adult CRS patients who underwent sinus surgery between 2020 and 2023 and a non-CRS control group; both groups were comparable in terms of age and gender. The association between a history of COVID‑19 and CRS according to its phenotype and endotype was examined using cross tables and chi-square tests. We also analyzed self-reported and measured olfactory ability. Additionally, patients were asked about continuous preoperative use of inhaled corticosteroids.
Results: There was no association between CRS and COVID‑19. This applied both to CRS patients with or without nasal polyps (CRSwNP or CRSsNP) and to endotyping according to tissue eosinophilia. The majority of operated CRS patients were CRSwNP patients, predominantly male and younger compared to CRSsNP patients. CRSwNP presented eosinophilia 2.8 times more frequently than CRSsNP. CRSsNP patients had better reported and measured olfactory ability compared to CRSwNP patients. The measured olfactory ability of the CRS patients with COVID‑19 did not differ from that of CRS patients without C‑19. Preoperative use of inhaled corticosteroids was more frequent among CRSwNP patients than CRSsNP patients.
Conclusion: Chronic rhinosinusitis was neither a risk nor a protective factor for COVID‑19.
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| http://dx.doi.org/10.1007/s00106-024-01534-8 | DOI Listing |
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