Crosstalk between junctional membrane proteins is vital in the coordinated generation of cellular Ca signals. New evidence (Ivanova et al.) reveals the signaling lipid, phosphatidylinositol 4,5-bisphosphate (PIP) reaches across plasma membrane (PM)-endoplasmic reticulum (ER) junctions to regulate inositol 1,4,5-trisphosphate receptors, controlling the critical progression of local to global Ca signals mediating a spectrum of fundamental cellular responses.
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| http://dx.doi.org/10.1016/j.tcb.2024.11.004 | DOI Listing |
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Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. Electronic address:
Crosstalk between junctional membrane proteins is vital in the coordinated generation of cellular Ca signals. New evidence (Ivanova et al.) reveals the signaling lipid, phosphatidylinositol 4,5-bisphosphate (PIP) reaches across plasma membrane (PM)-endoplasmic reticulum (ER) junctions to regulate inositol 1,4,5-trisphosphate receptors, controlling the critical progression of local to global Ca signals mediating a spectrum of fundamental cellular responses.
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