AI Article Synopsis

  • - Cognitive Behavioral Therapy for Insomnia (CBT-I) is proven to be effective for treating insomnia, but its underlying neurophysiological mechanisms are not well understood.
  • - This narrative review explores various scientific fields such as psychology, neurophysiology, and immunology to uncover how CBT-I may positively impact the central nervous system, immune response, and brain structure.
  • - The review suggests that CBT-I enhances brain connectivity and gene expression linked to immune function, proposing an integrated model to guide future research into its neurophysiological effects.

Article Abstract

Cognitive behavioral therapy for insomnia (CBT-I) is a widely used psychological intervention known for its effectiveness in improving insomnia symptoms. However, the neurophysiological mechanisms underlying the cognitive-behavioral treatment of insomnia remain unclear. This narrative review aimed to elucidate the neurophysiological and molecular mechanisms of CBT-I, focusing on the fields of psychology, neurophysiology, neuroendocrinology, immunology, medical microbiology, epigenetics, neuroimaging and brain function. A comprehensive search was conducted using databases including: PubMed, Embase, PsycINFO and Web of Science, with customized search strategies tailored to each database that included controlled vocabulary and alternative synonyms. It revealed that CBT-I may have a beneficial effect on the central nervous system, boost the immune system, upregulate genes involved in interferon and antibody responses, enhance functional connectivity between the hippocampus and frontoparietal areas and increase cortical gray matter thickness. In conclusion, an integrated model is proposed that elucidates the mechanisms of CBT-I and offers a new direction for investigations into its neurophysiological mechanisms.

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Source
http://dx.doi.org/10.31083/j.jin2311200DOI Listing

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